Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation
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Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.P53 at the start of the 21st century: lessons from elephants.PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.How the evolution of multicellularity set the stage for cancer.The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis.APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.Pushing the Limits of Cancer Therapy: The Nutrient Game.Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells.Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells
P2860
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P2860
Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 March 2017
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Inhibiting the system xC-/glut ...... s with mutant-p53 accumulation
@en
Inhibiting the system xC-/glut ...... with mutant-p53 accumulation.
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type
label
Inhibiting the system xC-/glut ...... s with mutant-p53 accumulation
@en
Inhibiting the system xC-/glut ...... with mutant-p53 accumulation.
@nl
prefLabel
Inhibiting the system xC-/glut ...... s with mutant-p53 accumulation
@en
Inhibiting the system xC-/glut ...... with mutant-p53 accumulation.
@nl
P2093
P2860
P50
P356
P1476
Inhibiting the system xC-/glut ...... s with mutant-p53 accumulation
@en
P2093
Colin M House
Cuong P Duong
David S Liu
Helen B Pearson
Karen G Montgomery
Lars Abrahmsen
Matthew Read
Oliver M Fisher
Walid J Azar
P2860
P2888
P356
10.1038/NCOMMS14844
P407
P577
2017-03-28T00:00:00Z