Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsParkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designG2385R and I2020T Mutations Increase LRRK2 GTPase ActivityCapsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease.Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96.Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.RIP kinases: key decision makers in cell death and innate immunity.Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disordersSmall molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expressionLRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisLeucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.Structural and functional in silico analysis of LRRK2 missense substitutions.Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis
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P2860
Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Biochemical and molecular feat ...... roles in Parkinson's disease.
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Biochemical and molecular feat ...... roles in Parkinson's disease.
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type
label
Biochemical and molecular feat ...... roles in Parkinson's disease.
@en
Biochemical and molecular feat ...... roles in Parkinson's disease.
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prefLabel
Biochemical and molecular feat ...... roles in Parkinson's disease.
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Biochemical and molecular feat ...... roles in Parkinson's disease.
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P1433
P1476
Biochemical and molecular feat ...... roles in Parkinson's disease.
@en
P2093
Wongi Seol
P304
P356
10.5483/BMBREP.2010.43.4.233
P577
2010-04-01T00:00:00Z