Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling
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Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophagesSpatial and functional heterogeneities shape collective behavior of tumor-immune networksLipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.Single-cell variation leads to population invariance in NF-κB signaling dynamicsHIF-1α restricts NF-κB-dependent gene expression to control innate immunity signalsStimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection.Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features.Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switchNF-κB oscillations translate into functionally related patterns of gene expression.Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.Modulation of Macrophage Inflammatory Nuclear Factor κB (NF-κB) Signaling by Intracellular Cryptococcus neoformansLate-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages.Genome-wide siRNA screen of genes regulating the LPS-induced NF-κB and TNF-α responses in mouse macrophages.Mathematical Modeling of Streptococcus pneumoniae Colonization, Invasive Infection and Treatment.Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.Cracking the NF-κB code.Topology, dynamics, and heterogeneity in immune signaling.Redefining Signaling Pathways with an Expanding Single-Cell Toolbox.Signaling via the NFκB system.Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation.Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action.High-Content Quantification of Single-Cell Immune Dynamics.Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation.A Light-Controlled TLR4 Agonist and Selectable Activation of Cell SubpopulationsLPS-RS attenuation of lipopolysaccharide-induced acute lung injury involves NF-κB inhibition.Measurement of NF-κB Activation in TLR-Activated Macrophages.NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise.Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub.NF-κB, the Importance of Being Dynamic: Role and Insights in Cancer.Ikaros family zinc finger 1 regulates dendritic cell development and function in humans.Challenges of Decoding Transcription Factor Dynamics in Terms of Gene RegulationLPS-stimulated NF-κB p65 dynamic response marks the initiation of TNF expression and transition to IL-10 expression in RAW 264.7 macrophages
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Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 January 2014
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Switching of the relative domi ...... haride-induced NF-κB signaling
@en
Switching of the relative domi ...... aride-induced NF-κB signaling.
@nl
type
label
Switching of the relative domi ...... haride-induced NF-κB signaling
@en
Switching of the relative domi ...... aride-induced NF-κB signaling.
@nl
prefLabel
Switching of the relative domi ...... haride-induced NF-κB signaling
@en
Switching of the relative domi ...... aride-induced NF-κB signaling.
@nl
P2093
P2860
P1433
P1476
Switching of the relative domi ...... haride-induced NF-κB signaling
@en
P2093
Gordon L Hager
Qizong Lao
Rachel A Gottschalk
P2860
P356
10.1126/SCISIGNAL.2004764
P577
2014-01-14T00:00:00Z