Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
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Interactions of metals and Apolipoprotein E in Alzheimer's diseaseA synthetic peptide with the putative iron binding motif of amyloid precursor protein (APP) does not catalytically oxidize ironResveratrol: A Focus on Several Neurodegenerative DiseasesEarly life environment and developmental immunotoxicity in inflammatory dysfunction and diseaseResveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicityAmyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assembliesEvaluation of brain iron content based on magnetic resonance imaging (MRI): comparison among phase value, R2* and magnitude signal intensityAnion effects on sodium ion and acid molecule adduction to protein ions in electrospray ionization mass spectrometry.Synthesis and characterization of some water soluble Zn(II) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA.Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.Metal imaging in neurodegenerative diseases.Cholesterol increases ventricular volume in a rabbit model of Alzheimer's disease.Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseIncreased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.Role of metal dyshomeostasis in Alzheimer's disease.Targeting Metal-Aβ Aggregates with Bifunctional Radioligand [(11)C]L2-b and a Fluorine-18 Analogue [(18)F]FL2-bPharmacological activity of metal binding agents that alter copper bioavailability.Fe(III) Is Essential for Porcine Embryonic Development via Mitochondrial Function MaintenanceA multifunctional, light-activated prochelator inhibits UVA-induced oxidative stressProchelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelationDietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortexProbing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiolsDistinctive Pattern of Serum Elements During the Progression of Alzheimer's Disease.Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.Clawing back: broadening the notion of metal chelators in medicineCellular transport and homeostasis of essential and nonessential metals.Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptomsZn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's diseaseYeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress.The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders.Metal ions, Alzheimer's disease and chelation therapy.Mechanisms of amyloid fibril formation--focus on domain-swapping.Metallothionein and brain inflammation.Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.
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P2860
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 02 May 2010
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en-gb
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@nl
type
label
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en-gb
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@nl
prefLabel
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en-gb
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@nl
P1476
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
@en
P356
10.1016/J.PNEUROBIO.2010.04.003
P577
2010-05-02T00:00:00Z