TAK1 regulates resident macrophages by protecting lysosomal integrity.
about
Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1.TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke.
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TAK1 regulates resident macrophages by protecting lysosomal integrity.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 February 2017
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@en
TAK1 regulates resident macrophages by protecting lysosomal integrity.
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type
label
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@en
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@nl
prefLabel
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@en
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@nl
P2093
P2860
P50
P356
P1476
TAK1 regulates resident macrophages by protecting lysosomal integrity.
@en
P2093
Giichi Takaesu
Julie F Foley
September R Mihaly
Yosuke Sakamachi
P2860
P356
10.1038/CDDIS.2017.23
P577
2017-02-09T00:00:00Z