CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases.
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Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptorsEmerging therapies for severe asthmaPathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriersThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors15-Deoxy-Δ12,14-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction.Opposing roles of prostaglandin D2 receptors in ulcerative colitisStraightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up.Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity.Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemiaInnate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine.Novel targeted therapies for eosinophilic disordersRole of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents.Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthmaNovel CRTH2 antagonists: a review of patents from 2006 to 2009.Pathophysiology of allergic inflammation.Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators.Prostanoids receptors signaling in different diseases/cancers progression.Targeting eosinophils in allergy, inflammation and beyond.Proinflammatory and immunoregulatory roles of eicosanoids in T cells.Biological Modulators in Eosinophilic Diseases.Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.Looking forward to new targeted treatments for chronic spontaneous urticaria.Investigational prostaglandin D2 receptor antagonists for airway inflammation.Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.Prostaglandin D2 receptor antagonists in early development as potential therapeutic options for asthma.Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus.15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.Discovery of AMG 853, a CRTH2 and DP Dual AntagonistBenzodiazepinone Derivatives as CRTH2 AntagonistsProstaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets.Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate.Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.Disposition and metabolism of setipiprant, a selective oral CRTH2 antagonist, in humans.Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders.Pathological and therapeutic roles of innate lymphoid cells in diverse diseases.Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists in asthma: a systematic review and meta-analysis protocol.
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CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 June 2010
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@en
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@nl
type
label
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@en
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
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prefLabel
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@en
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@nl
P2093
P356
P1433
P1476
CRTH2 and D-type prostanoid re ...... nts for inflammatory diseases.
@en
P2093
Bernhard A Peskar
Maria Waldhoer
Miriam Sedej
Petra Luschnig
Rufina Schuligoi
Sonia Philipose
P304
P356
10.1159/000313836
P577
2010-06-16T00:00:00Z