Defending the end zone: studying the players involved in protecting chromosome ends
about
Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factorsPot1a prevents telomere dysfunction and ATM-dependent neuronal loss.Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss.Essential roles for Pot1b in HSC self-renewal and survival.Critical role of the POT1 OB domain in maintaining genomic stability.p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.Human telomerase expression regulation.Chromosomal aberrations involving telomeres and interstitial telomeric sequences.Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus.The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.p53 pathway activation by telomere attrition in X-DC primary fibroblasts occurs in the absence of ribosome biogenesis failure and as a consequence of DNA damage.
P2860
Q28478698-F8E66BF8-2523-4F31-9663-EB823C876964Q31163246-A1B23B50-8FC6-40E9-A181-91C7D8F711E2Q33926851-46C91A1E-727F-403A-B27A-8BCEA73E2AF9Q35604048-55B6DE0C-57CB-4C7C-BFC8-FF951A56DBBBQ36199213-44557266-2C1A-4519-9029-87708A010574Q37200881-57E838D2-6A2E-46B8-B3D1-65AEFE3C9446Q37905799-3AEDE69A-D521-496C-965D-A78F96623B3DQ37920517-2AC5CDF9-900A-4928-900D-C094BE341AEFQ41984776-482591BC-FC3F-469E-A77E-AA881F2293B3Q42853694-396AAC3D-B4F8-424C-B10D-4F9AD0922357Q53088995-03C753E1-C394-4293-AF8F-BBD41C44267A
P2860
Defending the end zone: studying the players involved in protecting chromosome ends
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Defending the end zone: studying the players involved in protecting chromosome ends
@en
Defending the end zone: studying the players involved in protecting chromosome ends.
@nl
type
label
Defending the end zone: studying the players involved in protecting chromosome ends
@en
Defending the end zone: studying the players involved in protecting chromosome ends.
@nl
prefLabel
Defending the end zone: studying the players involved in protecting chromosome ends
@en
Defending the end zone: studying the players involved in protecting chromosome ends.
@nl
P2860
P1433
P1476
Defending the end zone: studying the players involved in protecting chromosome ends
@en
P2093
Sandy Chang
Suzanne S Chan
P2860
P304
P356
10.1016/J.FEBSLET.2010.06.016
P407
P577
2010-06-19T00:00:00Z