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An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiationT Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.The actin-bundling protein L-plastin supports T-cell motility and activationRho GTPases as pathogen targets: Focus on curable sexually transmitted infectionsT cell activation requires force generationF-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activationCD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.Cytoskeletal forces during signaling activation in Jurkat T-cells.F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.Morphological change of CD4(+) T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapseDNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.Actin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityFunctions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.Proteomics identifies differentially expressed proteins in neonatal murine thymus compared with adults.Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderlyA new look at T cell receptor signaling to nuclear factor-κBRatiometric imaging of the T-cell actin cytoskeleton reveals the nature of receptor-induced cytoskeletal enrichmentMast cell desensitization inhibits calcium flux and aberrantly remodels actin.The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.T cell antigen receptor activation and actin cytoskeleton remodeling.Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?Effects of Gekko sulfated polysaccharide-protein complex on the defective biorheological characters of dendritic cells under tumor microenvironment.The actin-bundling protein L-plastin: a critical regulator of immune cell function.Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells.Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.Adhesion-dependent modulation of actin dynamics in Jurkat T cells.
P2860
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P2860
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 August 2010
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mediation of T-cell activation by actin meshworks
@en
Mediation of T-cell activation by actin meshworks.
@nl
type
label
Mediation of T-cell activation by actin meshworks
@en
Mediation of T-cell activation by actin meshworks.
@nl
prefLabel
Mediation of T-cell activation by actin meshworks
@en
Mediation of T-cell activation by actin meshworks.
@nl
P2860
P1476
Mediation of T-cell activation by actin meshworks
@en
P2093
Matthew F Krummel
Peter Beemiller
P2860
P304
P356
10.1101/CSHPERSPECT.A002444
P577
2010-08-11T00:00:00Z