The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
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Chromosomal instability and cancer: a complex relationship with therapeutic potentialNon-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell DivisionUbiquitin-Mediated Degradation of Aurora KinasesDevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsAshwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activityIdentification of small molecule inhibitors of the Aurora-A/TPX2 complexTargeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.Weighted frequent gene co-expression network mining to identify genes involved in genome stability.ZNF385B and VEGFA are strongly differentially expressed in serous ovarian carcinomas and correlate with survivalFunctional analysis of prognostic gene expression network genes in metastatic breast cancer models.Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forcesPhosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.Aurora A kinase (AURKA) in normal and pathological cell division.Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancerGTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR SpectroscopyGlioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumorsControl of Aurora-A stability through interaction with TPX2.Identification of key genes for laryngeal squamous cell carcinoma using weighted co-expression network analysis.The structure of C290A:C393A Aurora A provides structural insights into kinase regulation.The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation.FAM83D, a microtubule-associated protein, promotes tumor growth and progression of human gastric cancer.Development of a multipurpose scaffold for the display of peptide loops.
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The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 12 August 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@en
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
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type
label
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@en
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@nl
prefLabel
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@en
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@nl
P2093
P1476
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
@en
P2093
Catherine Lindon
Giulia Guarguaglini
Italia Anna Asteriti
Patrizia Lavia
Wilhelmina Maria Rensen
P304
P356
10.1016/J.BBCAN.2010.08.001
P407
P577
2010-08-12T00:00:00Z