Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
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Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismReevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascadesA phosphodiesterase 2A isoform localized to mitochondria regulates respirationStructure-based development of novel sirtuin inhibitors.Characterization of apoptosis-related oxidoreductases from Neurospora crassa.Identification of a haem domain in human soluble adenylate cyclase.Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis.Structural studies and anticancer activity of a novel class of β-peptides.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells.Mitochondrial sirtuins--a new therapeutic target for repair and protection in multiple sclerosis.New assays and approaches for discovery and design of Sirtuin modulators.Ethyl gallate induces apoptosis of HL-60 cells by promoting the expression of caspases-8, -9, -3, apoptosis-inducing factor and endonuclease G.Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice.Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation.
P2860
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P2860
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 September 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@en
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@nl
type
label
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@en
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@nl
prefLabel
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@en
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@nl
P1476
Emerging mitochondrial signali ...... rocesses, and as drug targets.
@en
P2093
Clemens Steegborn
Mahadevan Lakshminarasimhan
P304
P356
10.1016/J.EXGER.2010.08.024
P577
2010-09-16T00:00:00Z