The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival.
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The Role of PTEN in Myeloid MalignanciesAdult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.Signaling specificity in the Akt pathway in biology and disease.A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells.Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA RepairControlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis.Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis.Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway.CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-cateninCasein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways.Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver DiseaseThe pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia.Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor.Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity.CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia.Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.New insights on thyroid hormone mediated regulation of herpesvirus infections.Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling.Proposal of a genetic classifier for risk group stratification in pediatric T-cell lymphoblastic lymphoma reveals differences from adult T-cell lymphoblastic leukemia.Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism.Design, synthesis, and evaluation of 4,5,6,7-tetrahydrobenzo[]thiazole-based novel dual kinase inhibitors of CK2 and GSK3β
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P2860
The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The impact of PTEN regulation ...... ng and leukemia cell survival.
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The impact of PTEN regulation ...... ng and leukemia cell survival.
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type
label
The impact of PTEN regulation ...... ng and leukemia cell survival.
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The impact of PTEN regulation ...... ng and leukemia cell survival.
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The impact of PTEN regulation ...... ng and leukemia cell survival.
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The impact of PTEN regulation ...... ng and leukemia cell survival.
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P1476
The impact of PTEN regulation ...... ng and leukemia cell survival.
@en
P356
10.1016/J.ADVENZREG.2010.09.012
P577
2010-10-28T00:00:00Z