Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.
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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionPharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agentsMechanism of Platinum Derivatives Induced Kidney InjuryDevelopment of Human Membrane Transporters: Drug Disposition and PharmacogeneticsThe role of drug transporters in the kidney: lessons from tenofovirOATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamiliesNuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytesRole of solute carriers in response to anticancer drugsThe first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio).Renal drug transporters and their significance in drug-drug interactionsMetformin and metabolic diseases: a focus on hepatic aspectsHepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 geneDNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinomaProton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assaysInhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-GlycoproteinEvolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence MotifsProtein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerizationCommon drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake.Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug dispositionDirect effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma.Molecular modeling and ligand docking for solute carrier (SLC) transportersDiscovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modelingBile formation and secretion.Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection.Differences between opioids: pharmacological, experimental, clinical and economical perspectivesRenal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals.Cardiovascular impact of drugs used in the treatment of diabetesToxicity of ionic liquids: eco(cyto)activity as complicated, but unavoidable parameter for task-specific optimization.Intracellular drug concentrations.Metformin as an energy restriction mimetic agent for breast cancer preventionPrevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.Rapid nongenomic actions of inhaled corticosteroids on long-acting β(2)-agonist transport in the airwayDeficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice.Reversing the reduced level of endometrial GLUT4 expression in polycystic ovary syndrome: a mechanistic study of metformin action.Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.Interaction of innovative small molecule drugs used for cancer therapy with drug transporters.Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.
P2860
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P2860
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Organic cation transporters (O ...... he importance in drug therapy.
@en
Organic cation transporters (O ...... he importance in drug therapy.
@nl
type
label
Organic cation transporters (O ...... he importance in drug therapy.
@en
Organic cation transporters (O ...... he importance in drug therapy.
@nl
prefLabel
Organic cation transporters (O ...... he importance in drug therapy.
@en
Organic cation transporters (O ...... he importance in drug therapy.
@nl
P2093
P1476
Organic cation transporters (O ...... he importance in drug therapy.
@en
P2093
Hermann Koepsell
Katja Damme
Matthias Schwab
P304
P356
10.1007/978-3-642-14541-4_3
P50
P577
2011-01-01T00:00:00Z