about
Specialized Cilia in Mammalian Sensory SystemsAdvances in understanding the molecular basis of the first steps in color visionRod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approachesRetina, retinol, retinal and the natural history of vitamin A as a light sensorIntrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions.PubChem structure–activity relationship (SAR) clustersRPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell modelChemistry of the retinoid (visual) cycleOptical imaging of human cone photoreceptors directly following the capture of lightAlpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activityRDH13L, an enzyme responsible for the aldehyde-alcohol redox coupling reaction (AL-OL coupling reaction) to supply 11-cis retinal in the carp cone retinoid cycleGene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.Retinal gene delivery by rAAV and DNA electroporation.Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.Retention of good visual acuity in eyes with neovascular age-related macular degeneration and chronic refractory subfoveal subretinal fluidBlue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate.Rational Tuning of Visual Cycle Modulator PharmacodynamicsCone outer segment extracellular matrix as binding domain for interphotoreceptor retinoid-binding protein.Chromophore supply rate-limits mammalian photoreceptor dark adaptation.Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapyImprovement and decline in vision with gene therapy in childhood blindness.Müller glial cell reprogramming and retina regeneration.The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein.CRALBP supports the mammalian retinal visual cycle and cone vision.Melanopsin tristability for sustained and broadband phototransductionRegeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein.Interphotoreceptor retinoid-binding protein protects retinoids from photodegradationKey enzymes of the retinoid (visual) cycle in vertebrate retinaActivated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosisThe visual system of zebrafish and its use to model human ocular diseases.Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations.Chemistry and biology of visionMelanopsin and mechanisms of non-visual ocular photoreception.Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout miceThe Effects of Diabetic Retinopathy and Pan-Retinal Photocoagulation on Photoreceptor Cell Function as Assessed by Dark AdaptometryMelanopsin is highly resistant to light and chemical bleaching in vivo.An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesisStructure of zebrafish IRBP reveals fatty acid binding
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
The cone-specific visual cycle.
@en
The cone-specific visual cycle.
@nl
type
label
The cone-specific visual cycle.
@en
The cone-specific visual cycle.
@nl
prefLabel
The cone-specific visual cycle.
@en
The cone-specific visual cycle.
@nl
P2860
P1476
The cone-specific visual cycle.
@en
P2093
Jin-Shan Wang
Vladimir J Kefalov
P2860
P304
P356
10.1016/J.PRETEYERES.2010.11.001
P577
2010-11-25T00:00:00Z