Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates.
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Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level.Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.A new mechanism of allostery in a G protein-coupled receptor dimerA two-step target binding and selectivity support vector machines approach for virtual screening of dopamine receptor subtype-selective ligandsStructure-guided development of heterodimer-selective GPCR ligandsAutomated design of ligands to polypharmacological profiles.Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonistsMulticomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.Allosteric Modulators of the Class A G Protein Coupled Receptors.A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus.Characterization of [(3) H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand.Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysisCross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergicsPersistence of associations between cognitive impairment and motor dysfunction in the early phase of Parkinson's disease.Multi-objective molecular de novo design by adaptive fragment prioritization.Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides.Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study.Predicting subtype selectivity of dopamine receptor ligands with three-dimensional biologically relevant spectrum.Fast and efficient (18) F-labeling by [(18) f]fluorophenylazocarboxylic esters.A new era of rationally designed antipsychotics.Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D receptor agonistsSelectivity and activation of dopamine D3R from molecular dynamics
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P2860
Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 January 2011
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Recent advances in the search ...... probes, models and candidates.
@en
Recent advances in the search ...... probes, models and candidates.
@nl
type
label
Recent advances in the search ...... probes, models and candidates.
@en
Recent advances in the search ...... probes, models and candidates.
@nl
prefLabel
Recent advances in the search ...... probes, models and candidates.
@en
Recent advances in the search ...... probes, models and candidates.
@nl
P1476
Recent advances in the search ...... probes, models and candidates.
@en
P2093
Harald Hübner
Stefan Löber
P304
P356
10.1016/J.TIPS.2010.12.003
P577
2011-01-12T00:00:00Z