about
Cloning and characterization of human liver cytosolic beta-glycosidaseDiscovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.Gene doping: an overview and current implications for athletes.Gene doping.Protein transduction domains and their utility in gene therapy.Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.Step into the groove: engineered transcription factors as modulators of gene expression.HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.Histone acetyl transferases as emerging drug targets.Pharmacological interventions for improving adenovirus usage in gene therapy.Endosomal escape pathways for delivery of biologicals.A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment.Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo.In vivo evaluation of [18F]FEAnGA-Me: a PET tracer for imaging β-glucuronidase (β-GUS) activity in a tumor/inflammation rodent model.Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished.Synthesis and evaluation of [18F]-FEAnGA as a PET Tracer for beta-glucuronidase activity.Selective targeting of adenovirus to alphavbeta3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies.Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages.PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.Highly efficient and carcinoma-specific adenoviral replication restricted by the EGP-2 promoter.Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors.Liposome-mediated targeting of enzymes to cancer cells for site-specific activation of prodrugs: comparison with the corresponding antibody-enzyme conjugate.Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.A new application for liposomes in cancer therapy. Immunoliposomes bearing enzymes (immuno-enzymosomes) for site-specific activation of prodrugs.Analysis of a conjugate between anti-carcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate.Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene.Secreted and tumour targeted human carboxylesterase for activation of irinotecanAdenovirus retargeting to surface expressed antigens on oral mucosa.Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative.Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin.Human IgM monoclonal antibody 16.88: pharmacokinetics and immunogenicity in colorectal cancer patients.Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation.A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.
P50
Q24291287-FF2FC87F-58A0-465F-993D-624F9349EEB6Q33595066-968C4F27-864C-4091-AACC-3E1E8E31C3EEQ33866592-6A879DFD-18D3-49BC-B895-197DDE15B025Q34322797-4C3FE8EE-EA56-44AD-B485-7BBAA380FA92Q34506875-1F118F0D-2C41-4D78-9CB1-0CF36977DD3CQ35551773-78E96479-871E-44B5-B1E2-C60A3924555AQ35574091-94DA1F96-7A88-47C7-8A89-D56CE0439470Q35994452-10677E22-B19D-4713-96E2-145FBFDD83D6Q36115888-44379135-4C1D-4D2F-A6DE-73E59B546ED5Q36492700-774989A7-383E-433A-A967-7613BE239BCCQ36834101-11802FAD-C2F9-474E-9B7D-93BAC2F4ACA5Q37540911-79541097-C141-41C0-AF7A-C212AFDCF75EQ37803397-ACA6381A-0D34-4AA2-B758-BFCC75E3C203Q37809596-7A0AB07F-0B6F-41DD-9D91-145979CAD65DQ38282674-DA51C29E-6C73-4B12-B584-676BBE783153Q38306285-294A45A9-D6A3-4A13-AA91-1C62AB2D2017Q39099353-3BBD47DB-9230-44F6-9CDE-04732F9444BFQ39374582-6ECD950B-2196-4096-8C02-DC37E17409D4Q39682744-1A6FAA76-2593-4BA7-A4D2-34AAE727E986Q39711463-FEBE52A9-7593-41E3-987B-B54A08120E8BQ39730829-6E825303-AD82-474F-9C41-827816256816Q39901151-C8686CFC-6804-46F5-B62A-7C42C318FE76Q39990946-B6AB1549-5110-4E1E-9CBB-D1201F682F6EQ40020932-B9E7ED23-5B46-449B-92EA-B15C3A3D2FB6Q40202437-CAD9D43A-BD5A-466D-AD41-0349D5D12C51Q40361993-95B966E4-6B7A-428C-A88F-3DFD93F939CDQ40628834-BE86D9BB-7387-4536-8B84-3986E27CEAD9Q40659460-461B764D-536F-4DFC-9BB6-8AF80869B380Q40820608-2EE083E0-0C68-434F-B997-4C85FA4AA9C9Q41507993-E3C42051-23E6-4528-A783-921BAC777598Q41646736-044C66BA-7B5B-48BB-9483-C4E73F9304DDQ42136598-B2387FD1-D9F6-4298-874E-74C0B402A061Q42279091-48B72642-7C94-4663-B224-C9738530FE2CQ42469918-3E12DE73-D182-49E3-807E-03E0757581EEQ42959572-0FF798C0-942B-4861-921A-F9B3E75317C6Q44461930-A0DABD95-C31C-4B50-BC23-B8284CFA23B7Q44507615-82E68CCC-61C0-434B-9419-DBA3336780E2Q44520881-945316AF-0997-432D-AD93-2851774C31FAQ44896823-C4BF5E03-D33D-481F-BD27-18B5813B8B85Q44927719-8FD5D678-4D22-4BA0-BF13-80C4495E6AF8
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Hidde Haisma
@nl
Hidde J Haisma
@sl
Hidde J. Haisma
@en
Hidde J. Haisma
@es
type
label
Hidde Haisma
@nl
Hidde J Haisma
@sl
Hidde J. Haisma
@en
Hidde J. Haisma
@es
altLabel
H. Haisma
@nl
H.J. Haisma
@nl
Hidde J Haisma
@nl
prefLabel
Hidde Haisma
@nl
Hidde J Haisma
@sl
Hidde J. Haisma
@en
Hidde J. Haisma
@es
P1053
E-8964-2014
P106
P21
P31
P3829
P496
0000-0003-3997-9052
P569
2000-01-01T00:00:00Z
P734
P735
P7449
PRS1242569