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The human steroid hydroxylases CYP1B1 and CYP11B2Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondriaThe "Bringer" strategy: a very fast and highly efficient method for construction of mutant libraries by error-prone polymerase chain reaction of ring-closed plasmids.Anti-CYP4Z1 autoantibodies detected in breast cancer patients.Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis.Comparative Proteome Analysis in Schizosaccharomyces pombe Identifies Metabolic Targets to Improve Protein Production and Secretion.Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast.Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes.Comparison of cytochrome P450 expression in four different human osteoblast models.CYP4Z1 - A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer.Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe.Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol.Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors.Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.Bystander signaling via oxidative metabolism.ROS production by adrenodoxin does not cause apoptosis in fission yeast.Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe.Challenges of steroid biotransformation with human cytochrome P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces pombe.Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe.CYP21-catalyzed production of the long-term urinary metandienone metabolite 17beta-hydroxymethyl-17 alpha-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping.Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.Expression and secretion of a CB4-1 scFv-GFP fusion protein by fission yeast.Engineering of human CYP3A enzymes by combination of activating polymorphic variants.Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertThe adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria.Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1).Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine.Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe.The human mineralocorticoid receptor only partially differentiates between different ligands after expression in fission yeast.A fluorimetric assay for cortisol.S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells.Inhibition of aldosterone biosynthesis by staurosporine.Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast.Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase.A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT).
P50
Q24321759-EC45D5F2-9795-4094-8BCF-DC8CD724EA5BQ28253831-AAC2D364-C38E-4E77-9320-F7C20143C023Q31065550-4421537C-5D98-42EE-B847-858EBBF4C6C7Q33920157-3C837B8C-8611-490F-8A75-D43EC4CB1145Q34906403-8642C381-A3A9-49DF-939E-88983787F1EDQ34983050-B7B18C27-F1F0-4CEB-B693-E89E3C4E0FEAQ36091284-215871C4-E193-4AA5-87F6-AF4C85815FD6Q37810183-DE61299E-8076-4BBC-8E1A-BAD8500AE3EEQ37810229-F8DD6BE3-D20D-47E2-A76E-9C00B590B9D0Q38695678-262FA70B-AD84-415D-B257-310477D05A81Q39125799-2021C8AF-2C1F-4E3D-B65F-CFC8A237701EQ40164114-7849399D-540B-4306-A6D0-7E6405B5641DQ40390269-592FC4DA-E0E5-4E9D-9A64-F261594BC741Q40446016-07AE0D83-AA11-4EA3-B17B-5A9A8EB54F9BQ40677152-A490518C-A6BB-412F-BD9A-28B0C1F0F17BQ40715882-DCCFBAB9-F4D0-42C8-B45C-064A33577FBCQ41347995-3F262404-BC92-4BD1-B0EE-04A283625196Q42519169-A6189140-FF46-4CDB-8DC0-539A5DCE8A94Q42716562-E6D5CC17-71E0-4A5B-B12F-D2767997A0B6Q42930736-FD9D519D-33AD-4FD6-AF53-4615FD27224CQ43173167-D60CFBA6-86E9-4312-B561-D19C56B6AE13Q43223071-2E0032FC-1747-4401-A886-3392A6B48900Q43240515-0F773F0F-6EB6-437F-924E-FD2F1DE8BED8Q43452734-714FD597-B7D8-44DF-9EA7-2B542A1F1CA5Q43883487-035A8EE2-693C-4AF7-9BC2-F39AD2FEAD49Q44144094-CF1F70B7-CDFD-48A4-8048-DB32C1C2CEDFQ44272818-A5BD40D5-DC9B-49C1-AAFF-4EA9A0CFE2F6Q44889550-09A0EB36-3FB5-41BF-B15E-F51FE635E528Q44953721-E9EDFDCF-45C4-4B13-9E5E-C570B146B8E8Q45307710-D17CCA53-8EA9-47DB-B9EC-E616ECDF5575Q46168208-8569C1C4-8675-4852-8BFD-8957717E2401Q46394358-52AD42A0-60B2-4AE4-906B-9F464474DE7DQ46394363-2BA18472-0DD6-4C61-A407-AF5821C66BBDQ46699744-81FE6A98-7CCF-44B1-9FE2-8B215B937117Q46710872-48DA1E22-E744-476C-AB25-B34BE90D8A8FQ46737597-2C19C342-08F7-4825-A3EF-7894D4D15E59Q47739536-417001D6-7EAA-4033-A022-43B66098BF26Q51639503-7433927A-E563-463C-898D-E307170FBD47Q52803920-84437EFF-53B9-4662-BFA5-605FA45997BEQ52807460-4B9DE3B5-D291-4605-B92A-9BEF4F8A9949
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Matthias Bureik
@ast
Matthias Bureik
@en
Matthias Bureik
@es
Matthias Bureik
@nl
Matthias Bureik
@sl
type
label
Matthias Bureik
@ast
Matthias Bureik
@en
Matthias Bureik
@es
Matthias Bureik
@nl
Matthias Bureik
@sl
prefLabel
Matthias Bureik
@ast
Matthias Bureik
@en
Matthias Bureik
@es
Matthias Bureik
@nl
Matthias Bureik
@sl
P1053
J-9677-2015
P106
P21
P2798
P31
P496
0000-0002-9515-6248