about
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4Generation and characterization of B7-H4/B7S1/B7x-deficient miceB cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cellsDominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyThe sound of silence: modulating anergy in T lymphocytes.STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and functionFunctional STAT3 deficiency compromises the generation of human T follicular helper cells.Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficienciesNaive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.The role of SAP and SLAM family molecules in the humoral immune response.Regulation of T follicular helper cell formation and function by antigen presenting cells.The regulation and role of T follicular helper cells in immunity.T cell-B cell interactions in primary immunodeficiencies.The good, the bad and the ugly - TFH cells in human health and disease.Human T follicular helper (Tfh) cells and disease.STAT3 is a central regulator of lymphocyte differentiation and function.Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.Erratum: The circulating life of a memory T-follicular helper cell.Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses.Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.The TORC that Gets the GC Cycling.B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.Decision criteria for resolving isotype switching conflicts by B cells.c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation, function and EBV immunity.TCR affinity and negative regulation limit autoimmunityDisruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiencyHuman Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21c-Rel but not NF-κB1 is important for T regulatory cell developmentImmunology: Helpful T cells are stickyHuman IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activityElucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndromeGermline-activating mutations in PIK3CD compromise B cell development and function
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Elissa K Deenick
@nl
Elissa K Deenick
@sl
Elissa K. Deenick
@en
Elissa K. Deenick
@es
type
label
Elissa K Deenick
@nl
Elissa K Deenick
@sl
Elissa K. Deenick
@en
Elissa K. Deenick
@es
prefLabel
Elissa K Deenick
@nl
Elissa K Deenick
@sl
Elissa K. Deenick
@en
Elissa K. Deenick
@es
P106
P1153
6506538190
P21
P31
P496
0000-0002-9271-0004