Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides.
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Structural Basis of Potent and Broad HIV-1 Fusion Inhibitor CP32MStructure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimerDissociation of the trimeric gp41 ectodomain at the lipid–water interface suggests an active role in HIV-1 Env-mediated membrane fusionThe Type VI secretion system spike protein VgrG5 mediates membrane fusion during intercellular spread by pseudomallei group Burkholderia speciesViral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV-1 gp41.Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41.Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells.A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses.A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 glycoprotein with high potency and stability.Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation.HIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion.Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed in Nicotiana benthamianaComputer-Aided Approaches for Targeting HIVgp41.Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor.Structure-based identification of inhibitors targeting obstruction of the HIVgp41 N-heptad repeat trimer.Customizable de novo design strategies for DOCK: Application to HIVgp41 and other therapeutic targets.Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection.
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Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 January 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Insights into the mechanism of ...... ed by its inhibitory peptides.
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Insights into the mechanism of ...... ed by its inhibitory peptides.
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type
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Insights into the mechanism of ...... ed by its inhibitory peptides.
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Insights into the mechanism of ...... ed by its inhibitory peptides.
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Insights into the mechanism of ...... ed by its inhibitory peptides.
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Insights into the mechanism of ...... ed by its inhibitory peptides.
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P2860
P1476
Insights into the mechanism of ...... led by its inhibitory peptides
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P2093
Yechiel Shai
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10.1007/S00249-010-0666-Z
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2011-01-22T00:00:00Z