about
Opposing activities protect against age-onset proteotoxicityReduced IGF-1 signaling delays age-associated proteotoxicity in miceA multi-animal tracker for studying complex behaviors.Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells.Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: current knowledge and future prospects.Ageing and protein aggregation-mediated disorders: from invertebrates to mammals.Quality control compartments coming of age.Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities.Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders.The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.The roles of cellular and organismal aging in the development of late-onset maladies.Protein Quality Control in Health and Disease.The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition.A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies.A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis.Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protectionA kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues.From mutated genes to familial Alzheimer's disease.Proteostasis collapse, inter-tissue communication, and the regulation of aging at the organismal level.Temporal requirements of heat shock factor-1 for longevity assurance.Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments.Vesicle-mediated secretion of misfolded prion protein molecules from cyclosporin A-treated cells.PrP-containing aggresomes are cytosolic components of an ER quality control mechanism.A neuronal GPCR is critical for the induction of the heat shock response in the nematode C. elegans.Differential regulation of the heat shock factor 1 and DAF-16 by neuronal nhl-1 in the nematode C. elegans.The Insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis inModulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegansGene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Ehud Cohen
@ast
Ehud Cohen
@en
Ehud Cohen
@es
Ehud Cohen
@nl
Ehud Cohen
@sl
type
label
Ehud Cohen
@ast
Ehud Cohen
@en
Ehud Cohen
@es
Ehud Cohen
@nl
Ehud Cohen
@sl
prefLabel
Ehud Cohen
@ast
Ehud Cohen
@en
Ehud Cohen
@es
Ehud Cohen
@nl
Ehud Cohen
@sl
P106
P21
P31
P496
0000-0001-5552-7086