about
Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domainB cells--masters of the immunoverse.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo.Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage.Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig.Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity.Antibody modulation: Limiting the efficacy of therapeutic antibodies
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrew T Vaughan
@ast
Andrew T Vaughan
@en
Andrew T Vaughan
@es
Andrew T Vaughan
@nl
Andrew T Vaughan
@sl
type
label
Andrew T Vaughan
@ast
Andrew T Vaughan
@en
Andrew T Vaughan
@es
Andrew T Vaughan
@nl
Andrew T Vaughan
@sl
prefLabel
Andrew T Vaughan
@ast
Andrew T Vaughan
@en
Andrew T Vaughan
@es
Andrew T Vaughan
@nl
Andrew T Vaughan
@sl
P106
P21
P31
P496
0000-0001-6076-3649