The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.
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Genome-scale engineering for systems and synthetic biologyFrom blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesisMendelian randomization: genetic anchors for causal inference in epidemiological studiesThe role of transposable elements in health and diseases of the central nervous systemIndependent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic EncephalopathyThe integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolutionReplication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination SurveyPleiotropy in complex traits: challenges and strategiesGlobal analysis of the human pathophenotypic similarity gene network merges disease module componentsGene duplication and phenotypic changes in the evolution of mammalian metabolic networksNetwork Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of MutationAnatomical Network Comparison of Human Upper and Lower, Newborn and Adult, and Normal and Abnormal Limbs, with Notes on Development, Pathology and Limb Serial Homology vs. HomoplasyGenetic architecture of growth traits revealed by global epistatic interactionsNetwork biology concepts in complex disease comorbiditiesThe genetic architecture of novel trophic specialists: larger effect sizes are associated with exceptional oral jaw diversification in a pupfish adaptive radiation.An Expanded View of Complex Traits: From Polygenic to OmnigenicAnalysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinicsOn the scent of pleiotropy.Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies.Adaptive divergence in experimental populations of Pseudomonas fluorescens. V. Insight into the niche specialist fuzzy spreader compels revision of the model Pseudomonas radiation.Returning pleiotropic results from genetic testing to patients and research participants.Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS dataLandscape genomics and a common garden trial reveal adaptive differentiation to temperature across Europe in the tree species Alnus glutinosa.Gene pleiotropy constrains gene expression changes in fish adapted to different thermal conditions.Aggressive behaviours, food deprivation and the foraging gene.Bayesian network reconstruction using systems genetics data: comparison of MCMC methodsThe emergence of complexity and restricted pleiotropy in adapting networks.Assessing duplication and loss of APETALA1/FRUITFULL homologs in Ranunculales.Fisher's geometrical model emerges as a property of complex integrated phenotypic networksGenetic Markers of Human Evolution Are Enriched in Schizophrenia.The genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection.Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.Mapping complex traits as a dynamic system.Adaptation to climate across the Arabidopsis thaliana genome.Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass indexRoles for modularity and constraint in the evolution of cranial diversity among Anolis lizards.The many faces of pleiotropy.Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.Quantifying and analyzing the network basis of genetic complexity
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The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The pleiotropic structure of t ...... vability of complex organisms.
@en
The pleiotropic structure of t ...... vability of complex organisms.
@nl
type
label
The pleiotropic structure of t ...... vability of complex organisms.
@en
The pleiotropic structure of t ...... vability of complex organisms.
@nl
prefLabel
The pleiotropic structure of t ...... vability of complex organisms.
@en
The pleiotropic structure of t ...... vability of complex organisms.
@nl
P2860
P356
P1476
The pleiotropic structure of t ...... lvability of complex organisms
@en
P2093
Jianzhi Zhang
P2860
P2888
P304
P356
10.1038/NRG2949
P577
2011-03-01T00:00:00Z