Therapeutic potential of FtsZ inhibition: a patent perspective.
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Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.Drug discovery targeting cell division proteins, microtubules and FtsZ.Benzimidazole-based antibacterial agents against Francisella tularensis.Characterization and in vitro inhibition studies of Bacillus anthracis FtsZ: a potential antibacterial target.TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model.Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivoSAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.Chlamydial biology and its associated virulence blockers.Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.Antibacterial activity of alkyl gallates against Xanthomonas citri subsp. citri.Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins.Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ.
P2860
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P2860
Therapeutic potential of FtsZ inhibition: a patent perspective.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 March 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Therapeutic potential of FtsZ inhibition: a patent perspective.
@en
Therapeutic potential of FtsZ inhibition: a patent perspective.
@nl
type
label
Therapeutic potential of FtsZ inhibition: a patent perspective.
@en
Therapeutic potential of FtsZ inhibition: a patent perspective.
@nl
prefLabel
Therapeutic potential of FtsZ inhibition: a patent perspective.
@en
Therapeutic potential of FtsZ inhibition: a patent perspective.
@nl
P2860
P1476
Therapeutic potential of FtsZ inhibition: a patent perspective.
@en
P2093
Divya Awasthi
Kunal Kumar
P2860
P304
P356
10.1517/13543776.2011.568483
P407
P50
P577
2011-03-18T00:00:00Z