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Bioactive lipids and the control of Bax pro-apoptotic activityBinding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterolsSpecific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and strokeVisualization of acute liver damage induced by cycloheximide in rats using PET with [(18)F]FEDAC, a radiotracer for translocator protein (18 kDa)Designing a compact high performance brain PET scanner-simulation studyPET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714.Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players.Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer.Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients.Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humansThe development of mitochondrial membrane affinity chromatography columns for the study of mitochondrial transmembrane proteins.Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging studyCurrent imaging strategies in rheumatoid arthritisA genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammationPET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma.Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcriptionDrug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cellsCurrent paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases.The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa.Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque.The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy.Imaging Pulmonary Inflammation.SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma modelThe translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo.Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA.Peptide targeting of mitochondria elicits testosterone formation.Differential influence of propofol and isoflurane anesthesia in a non-human primate on the brain kinetics and binding of [(18)F]DPA-714, a positron emission tomography imaging marker of glial activation.The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages.Conformational Flexibility in the Transmembrane Protein TSPOThe development of an automated and GMP compliant FASTlab™ Synthesis of [(18) F]GE-180; a radiotracer for imaging translocator protein (TSPO).Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?TSPO regulation in reactive gliotic diseases.Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases.6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients.Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1Δe9 transgenic mouse model of Alzheimer's disease.Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT.Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer's disease patients and control subjects.[18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 April 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The translocator protein.
@en
The translocator protein.
@nl
type
label
The translocator protein.
@en
The translocator protein.
@nl
prefLabel
The translocator protein.
@en
The translocator protein.
@nl
P1476
The translocator protein.
@en
P2093
Alana M Scarf
Michael Kassiou
P304
P356
10.2967/JNUMED.110.086629
P407
P577
2011-04-15T00:00:00Z