Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. - Wikidata - wikimedia - TriplyDB

Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release.

Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release.

http://www.wikidata.org/entity/Q37866109

about

A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis The structural biology of enzymes involved in natural product glycosylation Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) fromVibrio fischeriin complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial parasite Brugia malayi Study of intra-inter species protein-protein interactions for potential drug targets identification and subsequent drug design for Escherichia coli O104:H4 C277-11.Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae.EmmdR, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacae Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.Targeting the formation of the cell wall core of M. tuberculosis.Fosfomycin Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.Cytoplasmic steps of peptidoglycan biosynthesis.The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target.Peptidoglycan biosynthesis machinery: a rich source of drug targets.UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments.Will new antimicrobials overcome resistance among Gram-negatives?Fosfomycin: Mechanism and Resistance.Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa.CTX-M-15-producing urinary Escherichia coli O25b-ST131-phylogroup B2 has acquired resistance to fosfomycin.Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3.Identification of druggable targets for Acinetobacter baumannii via subtractive genomics and plausible inhibitors for MurA and MurB.Origin of the plasmid-mediated fosfomycin resistance gene fosA3.Nitrofurantoin and Fosfomycin for Extended Spectrum Beta-lactamases Producing Escherichia coli and Klebsiella pneumoniae.Iron-dependent essential genes in Salmonella Typhimurium Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

P2860

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P2860

Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release.

http://www.wikidata.org/entity/Q37866109

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Evidence that the fosfomycin t ...... essential for product release.

@en

Evidence that the fosfomycin t ...... samine enolpyruvyl transferase

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type

label

Evidence that the fosfomycin t ...... essential for product release.

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Evidence that the fosfomycin t ...... samine enolpyruvyl transferase

@nl

prefLabel

Evidence that the fosfomycin t ...... essential for product release.

@en

Evidence that the fosfomycin t ...... samine enolpyruvyl transferase

@nl

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Journal of Biological Chemistry

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Evidence that the fosfomycin t ...... essential for product release.

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P2093

Ernst Schönbrunn

http://www.w3.org/2001/XMLSchema#string

Melanie Priestman

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Susanne Eschenburg

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P2860

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail

Improved methods for building protein models in electron density maps and the location of errors in these models

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA

Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA

Comparative X-ray analysis of the un-liganded fosfomycin-target murA

Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold

How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli

A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states

P304

3757-3763

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10.1074/JBC.M411325200

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P698

15531591

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