Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic DrugsEmerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingCurrent and emergent treatments for symptoms and neurocognitive impairment in schizophrenia.The NMDA receptor as a target for cognitive enhancementGlutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders.Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology?Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family.Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to LightFunctional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers.Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression.A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signalingNMDA hypofunction as a convergence point for progression and symptoms of schizophreniaCholinergic connectivity: it's implications for psychiatric disorders.A review of use of enantiomers in homeopathy.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsNeurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.Calcium-dependent networks in dopamine-glutamate interaction: the role of postsynaptic scaffolding proteins.mGluR2 positive allosteric modulators: a patent review (2009 - present).Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.Beyond dopamine: glutamate as a target for future antipsychotics.Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268.Dissociable effects of the d- and l- enantiomers of govadine on the disruption of prepulse inhibition by MK-801 and apomorphine in male Long-Evans rats.Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.Development of PET and SPECT probes for glutamate receptors.Neonatal exposure to MK-801 reduces mRNA expression of mGlu3 receptors in the medial prefrontal cortex of adolescent rats.Age-Related Declines in Prefrontal Cortical Expression of Metabotropic Glutamate Receptors that Support Working Memory.Prospective Analysis of the Effects of Maternal Immune Activation on Rat Cytokines during Pregnancy and Behavior of the Male Offspring Relevant to Schizophrenia
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Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 May 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
@en
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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type
label
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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prefLabel
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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P2860
P1433
P1476
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
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P2093
Paige N Vinson
P2860
P304
P356
10.1016/J.NEUROPHARM.2011.05.005
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2011-05-19T00:00:00Z