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The Critical Roles of Zinc: Beyond Impact on Myocardial SignalingZinc transporter 8 (ZnT8) and β cell functionProton-dependent zinc release from intracellular ligandsTRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemiaHypoxia limits inhibitory effects of Zn2+ on spreading depolarizations.Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons.Cytosolic acidification and intracellular zinc release in hippocampal neuronsCharacterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model.Transition metals activate TFEB in overexpressing cellsZn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury?Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion.Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia.AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures.Metal-induced neurodegeneration in C. elegans.Intracellular Zn2+ accumulation enhances suppression of synaptic activity following spreading depolarization.Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currentsFerric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome.Copper and protons directly activate the zinc-activated channelMobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria.The interactive roles of zinc and calcium in mitochondrial dysfunction and neurodegeneration.Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular DementiaThe role of glutamate in neuronal ischemic injury: the role of spark in fire.Ca permeable AMPA channels in diseases of the nervous system.Thinking of Co²⁺-staining explant tissue or cultured cells? How to make it reliable and specific.Contribution of calcium-conducting channels to the transport of zinc ions.Zinc and insulin in pancreatic beta-cells.The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseasesDisruption of zinc homeostasis and the pathogenesis of senile dementia.Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?Intracellular Zn(2+) signaling in cognition.The CNS under pathophysiologic attack--examining the role of K₂p channels.Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage.Relationship between Zinc (Zn (2+) ) and Glutamate Receptors in the Processes Underlying Neurodegeneration.Autophagy Mediates Astrocyte Death During Zinc-Potentiated Ischemia--Reperfusion Injury.TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration.Zn2+ blocks annealing of complementary single-stranded DNA in a sequence-selective manner
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 May 2011
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Zinc: new clues to diverse roles in brain ischemia.
@en
Zinc: new clues to diverse roles in brain ischemia.
@nl
type
label
Zinc: new clues to diverse roles in brain ischemia.
@en
Zinc: new clues to diverse roles in brain ischemia.
@nl
prefLabel
Zinc: new clues to diverse roles in brain ischemia.
@en
Zinc: new clues to diverse roles in brain ischemia.
@nl
P2860
P1476
Zinc: new clues to diverse roles in brain ischemia.
@en
P2093
C William Shuttleworth
John H Weiss
P2860
P304
P356
10.1016/J.TIPS.2011.04.001
P577
2011-05-27T00:00:00Z