Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
about
Comprehensive analysis of protein digestion using six trypsins reveals the origin of trypsin as a significant source of variability in proteomics.Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges.LR12-peptide quantitation in whole blood by RP-HPLC and intrinsic fluorescence detection: Validation and pharmacokinetic study.Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics.Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based AssaysThe use of selected reaction monitoring in quantitative proteomics.Antigen generation and display in therapeutic antibody drug discovery -- a neglected but critical player.MS-based approaches to unravel the molecular complexity of proprotein-derived biomarkers and support their quantification: the examples of B-type natriuretic peptide and apelin peptides.Deciphering post-translational modification codes.Peptides as the next generation of anti-infectives.Life cycle management of critical ligand-binding reagents.Advances in the quantitation of therapeutic insulin analogues by LC-MS/MS.Application and challenges in using LC-MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery.The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis.Quantitation of human peptides and proteins via MS: review of analytically validated assays.Applications of low-flow LC-SRM for the analysis of large molecules in pharmaceutical R&D.Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays.Challenges for the in vivo quantification of brain neuropeptides using microdialysis sampling and LC-MS.An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.Application of high-resolution MS for development of peptide and large-molecule drug candidates.Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.Targeted LC-MS quantification of intact TAT-fusion therapeutics: a case study.Quantification of ghrelin and des-acyl ghrelin in human plasma by using cubic-selected reaction-monitoring LCMS.LC-MS/MS of large molecules in a regulated bioanalytical environment - which acceptance criteria to apply?2013 White Paper on recent issues in bioanalysis: 'hybrid'--the best of LBA and LCMS.LC-MS/MS quantification of parathyroid hormone fragment 1-34 in human plasma.Feasibility of microdialysis for determination of protein binding and target site pharmacokinetics of colistin in vivo.Minimalistic sample preparation strategies for LC-MS quantification of large molecule biopharmaceuticals: a case study highlighting alpha-1 antitrypsin protein.Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis.A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study.Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences.Message from the editors.Evaluation of the potential use of hybrid LC-MS/MS for active drug quantification applying the 'free analyte QC concept'.A novel sequential electrostatic-HILIC SPE within a quantitative method for bivalirudin in human plasma by LC-SRM.A whole-molecule immunocapture LC-MS approach for the in vivo quantitation of biotherapeutics.LC-MS quantification of protein drugs: validating protein LC-MS methods with predigestion immunocapture.Feasibility assessment of a novel selective peptide derivatization strategy for sensitivity enhancement for the liquid chromatography/tandem mass spectrometry bioanalysis of protein therapeutics in serum.Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.Case studies: the impact of nonanalyte components on LC-MS/MS-based bioanalysis: strategies for identifying and overcoming matrix effects.Bioanalytical method validation considerations for LC-MS/MS assays of therapeutic proteins.
P2860
Q33827075-3ADA84EF-1BC3-40B8-A2AA-175F8A58A111Q34191718-C21C72AF-BB30-4AE7-A423-A8171A9A2740Q36176857-48438527-DDF1-4F54-A733-B929442C0D96Q36331497-0448B5E9-13C2-457F-BCE9-F2E04B2388DAQ36794987-03802478-036D-43B9-9CEC-2FC13833841DQ38033244-FB60F4BB-05D7-48D0-9264-532B411FA35BQ38058763-ECBA0B41-40C6-4E52-B5AA-F7FBD5708FFBQ38065253-1EF6F310-3A0A-4D24-8F65-EFE3F8CC0131Q38080975-F9356DB6-D9E0-486B-8E3E-019D49C13330Q38086871-57EBCF31-5305-49FF-95E0-BF68AA7CE4AEQ38158185-427391A1-73D6-4CAF-A3BF-AB6DE1DFFD46Q38167831-338B3CEF-D7B1-4DEF-983E-228E3ACE2714Q38202150-83952C1F-390C-487B-90F8-D616F45E207CQ38243344-F4D54FC5-0B55-4312-9264-D1BFC1AB5880Q38243345-E6C22D74-06A2-4D30-BA48-C0374C24266EQ38243346-CFE1EF61-BEF9-4DA5-A121-7E2A8B79B7D3Q38500988-C885DB93-FBBD-41CE-8F74-6D179EAE69BCQ38935590-672A7D91-4D26-4E4C-8DA1-5CED3082E3E6Q38990711-D846E624-535B-4BF9-9B52-00C4B2FD1E5CQ40077940-DA9EAD4B-0A6C-4A04-AC0F-31AFB20F2C75Q41512147-3770B486-2454-4E00-B566-758F23F71E2CQ42173300-0D8CE57E-2780-4F16-B88A-060C17439252Q44229488-CF3974B2-51D5-40A1-82D5-45B55858A49DQ44315206-8B376DEE-4D80-41C0-A246-AD7676A6B187Q44843970-FA864022-2458-46E6-9FBB-C5B0B295C127Q45770022-D1F6BCAA-61CC-456C-B856-BB55CA63BE56Q46237714-39E93BEA-E7EE-4E4F-A430-6D98E27FCD26Q46847493-B320A4EC-2996-4CF3-B0A5-581F0266A656Q47368517-39FC5E31-C4A5-4926-8830-7AA042E7DC51Q47827462-C4B273B7-9678-4791-A524-EB70CD6CB10BQ48225243-0B75425F-83A3-4C20-B52D-7167A440681FQ48645840-4D07F3BD-6942-42CF-9F76-F63FCE12A343Q49789920-056F60AC-7BC6-40EC-82CB-DB47CD95C2DCQ51455053-3C34684D-E8E6-48E2-A416-029EE66B186BQ51525919-7114F866-5828-47CF-BD2C-56B67AEC8658Q51566920-1E32AD24-F160-427F-A1F9-2C4E6498D59EQ51751380-6C542E49-DF6A-4D2D-BDBC-D12A67D84606Q52737161-B397372E-27F7-450D-8E30-E802A07BF756Q53126964-BD6FD4DA-3C38-4810-AFF5-A05780F9A307Q53642158-7998581F-720A-499A-845B-1A742064161E
P2860
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@en
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@nl
type
label
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@en
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@nl
prefLabel
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@en
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@nl
P2860
P356
P1433
P1476
Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.
@en
P2093
Lee Goodwin
Matthew Ewles
P2860
P304
P356
10.4155/BIO.11.112
P577
2011-06-01T00:00:00Z