Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.
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Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brainThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseasePathologic and therapeutic implications for the cell biology of parkinMediation of organismal aging and somatic proteostasis by the germlineNicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from PellagraGene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.Structural basis for mutation-induced destabilization of profilin 1 in ALS.The ubiquitin E3 ligase parkin regulates the proapoptotic function of BaxThe use of next-generation sequencing in movement disordersPhysiological phenotype and vulnerability in Parkinson's diseaseCompartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity.The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.Intraneuronal β-amyloid and its interactions with proteins and subcellular organelles.Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.The role of protein clearance mechanisms in organismal ageing and age-related diseases.Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1.Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer's Disease.
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P2860
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@en
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@nl
type
label
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@en
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@nl
prefLabel
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@en
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@nl
P2860
P1476
Proteostasis and movement diso ...... amyotrophic lateral sclerosis.
@en
P2093
Daryl A Bosco
Matthew J LaVoie
P2860
P304
P356
10.1101/CSHPERSPECT.A007500
P577
2011-10-01T00:00:00Z