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Novel GPCR paradigms at the μ-opioid receptorRegulation of G protein-coupled receptors by allosteric ligandsStructural Basis for Allosteric Regulation of GPCRs by Sodium IonsInhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon ReceptorNovel Allosteric Modulators of G Protein-coupled ReceptorsThe second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancersAction of molecular switches in GPCRs--theoretical and experimental studies.Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids.A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulationNovel selective allosteric and bitopic ligands for the S1P(3) receptor.Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsMinireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryCarboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.Muscarinic acetylcholine receptors: novel opportunities for drug development.A common molecular motif characterizes extracellular allosteric enhancers of GPCR aminergic receptors and suggests enhancer mechanism of action.Drug Design Strategies for GPCR Allosteric Modulators.Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death.Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1.Allosteric modulation as a unifying mechanism for receptor function and regulation.
P2860
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P2860
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artículo científico
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name
Allostery in GPCRs: 'MWC' revisited.
@en
Allostery in GPCRs: 'MWC' revisited.
@nl
type
label
Allostery in GPCRs: 'MWC' revisited.
@en
Allostery in GPCRs: 'MWC' revisited.
@nl
prefLabel
Allostery in GPCRs: 'MWC' revisited.
@en
Allostery in GPCRs: 'MWC' revisited.
@nl
P2093
P50
P1476
Allostery in GPCRs: 'MWC' revisited
@en
P2093
Arthur Christopoulos
Meritxell Canals
Patrick M Sexton
P304
P356
10.1016/J.TIBS.2011.08.005
P577
2011-09-14T00:00:00Z