Lessons learned from molecular biology of insulin-gene mutations.
about
PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolismINS-gene mutations: from genetics and beta cell biology to clinical diseaseEnhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINSHexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotesAutoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patientsChiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainMutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transportA mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouseInsulin receptor substrate-1 variants in non-insulin-dependent diabetesProinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Rat model of food-induced non-obese-type 2 diabetes mellitus: comparative pathophysiology and histopathologyPolymorphism of glucokinase gene in non-insulin dependent diabetes mellitusA Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.Insulin: a small protein with a long journey.Insulin gene mutations and diabetesMutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secretedSorting and processing of secretory proteins.Evaluation of conformational changes in diabetes-associated mutation in insulin a chain: a molecular dynamics study.Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients.Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5' flanking region of the human insulin gene.
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P2860
Lessons learned from molecular biology of insulin-gene mutations.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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Lessons learned from molecular biology of insulin-gene mutations.
@en
Lessons learned from molecular biology of insulin-gene mutations.
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type
label
Lessons learned from molecular biology of insulin-gene mutations.
@en
Lessons learned from molecular biology of insulin-gene mutations.
@nl
prefLabel
Lessons learned from molecular biology of insulin-gene mutations.
@en
Lessons learned from molecular biology of insulin-gene mutations.
@nl
P2093
P356
P1433
P1476
Lessons learned from molecular biology of insulin-gene mutations.
@en
P2093
P304
P356
10.2337/DIACARE.13.6.600
P407
P577
1990-06-01T00:00:00Z