The structure and function of the glucagon-like peptide-1 receptor and its ligands
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Regulation of glucose homeostasis by GLP-1Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structureThe class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitusGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsConformational states of the full-length glucagon receptorStructural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptorGlucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domainA bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cellsThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsPurification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptorInsights into the structure of class B GPCRs.Could the improvement of obesity-related co-morbidities depend on modified gut hormones secretion?Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetesOral Delivery of Pentameric Glucagon-Like Peptide-1 by Recombinant Lactobacillus in Diabetic Rats.Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4Role of the gut in lipid homeostasisEngineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery.The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect.Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists.An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain.Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity.Effect of Laparoscopic Sleeve Gastrectomy on Fasting Gastrointestinal, Pancreatic, and Adipose-Derived Hormones and on Non-Esterified Fatty Acids.Cardiovascular Benefits of Native GLP-1 and its Metabolites: An Indicator for GLP-1-Therapy Strategies.Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor.Pharmacological characterization and antidiabetic activity of a long-acting glucagon-like peptide-1 analogue conjugated to an antithrombin III-binding pentasaccharide.Molecular Pharmacology of the Incretin Receptors.7TM Domain Structure of Adhesion GPCRs.A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.GLP-1-dependent and independent effects and molecular mechanisms of a dipeptidyl peptidase 4 inhibitor in vascular endothelial cells.A site-specific PEGylated analog of exendin-4 with improved pharmacokinetics and pharmacodynamics in vivo.The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.Visual Detection of Denatured Glutathione Peptides: A Facile Method to Visibly Detect Heat Stressed Biomolecules.Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions.Rate of Homologous Desensitization and Internalization of the GLP-1 Receptor.
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The structure and function of the glucagon-like peptide-1 receptor and its ligands
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
The structure and function of the glucagon-like peptide-1 receptor and its ligands
@en
The structure and function of the glucagon-like peptide-1 receptor and its ligands.
@nl
type
label
The structure and function of the glucagon-like peptide-1 receptor and its ligands
@en
The structure and function of the glucagon-like peptide-1 receptor and its ligands.
@nl
prefLabel
The structure and function of the glucagon-like peptide-1 receptor and its ligands
@en
The structure and function of the glucagon-like peptide-1 receptor and its ligands.
@nl
P2860
P1476
The structure and function of the glucagon-like peptide-1 receptor and its ligands
@en
P2093
Dan Donnelly
P2860
P356
10.1111/J.1476-5381.2011.01687.X
P407
P577
2012-05-01T00:00:00Z