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The controversial role of ABC transporters in clinical oncology.

The controversial role of ABC transporters in clinical oncology.

http://www.wikidata.org/entity/Q37941758

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Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Tissue-specific transcript profiling for ABC transporters in the sequestering larvae of the phytophagous leaf beetle Chrysomela populi Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein.Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.A high throughput flow cytometric assay platform targeting transporter inhibition ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer.Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy.Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis.Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.Enhanced brain accumulation of pazopanib by modulating P-gp and Bcrp1 mediated efflux with canertinib or erlotinib.Comprehensive multiplatform biomarker analysis of 199 anal squamous cell carcinomas.P-glycoprotein is fully active after multiple tryptophan substitutions Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4 Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing Breast cancer resistance protein (Bcrp) and the testis--an unexpected turn of events.Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists.Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention.Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics.Drug transporters in the central nervous system.Mechanisms and therapeutic potential of inhibiting drug efflux transporters.Drug transporters in breast cancer: response to anthracyclines and taxanes.MRP1 and its role in anticancer drug resistance.Mechanistic diversity in ATP-binding cassette (ABC) transporters.Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.Can the assessment of ABCB1 gene expression predict its function in vitro?Methylation of SFRP5 is related to multidrug resistance in leukemia cells.Detergent-free purification of ABC (ATP-binding-cassette) transporters.Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors.Therapy's Shadow: A Short History of the Study of Resistance to Cancer Chemotherapy.Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma.

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The controversial role of ABC transporters in clinical oncology.

http://www.wikidata.org/entity/Q37941758

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The controversial role of ABC transporters in clinical oncology.

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The controversial role of ABC transporters in clinical oncology.

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type

label

The controversial role of ABC transporters in clinical oncology.

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The controversial role of ABC transporters in clinical oncology.

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The controversial role of ABC transporters in clinical oncology.

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The controversial role of ABC transporters in clinical oncology.

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Essays in Biochemistry

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The controversial role of ABC transporters in clinical oncology

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Akina Tamaki

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Caterina Ierano

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Gergely Szakacs

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Susan E Bates

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P2860

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Targeting multidrug resistance in cancer

Tumour stem cells and drug resistance

Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia

Effect of valspodar on the pharmacokinetics of unbound paclitaxel.

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors.

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209-232

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10.1042/BSE0500209

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1

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21967059

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