Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
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Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivoryA genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao"Enzymogenesis": classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase lineA genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 allelesHuman CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLPEvolutionary biology of plant defenses against herbivory and their predictive implications for endocrine disruptor susceptibility in vertebrates.Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human clusterCalcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic InteractionsCoactivator recruitment of AhR/ARNT1Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptorFunctional evaluation of genetic and environmental regulators of p450 mRNA levelsCyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolismImportant role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistanceNeonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern HumansSpecifically expressed genes of the nematode Bursaphelenchus xylophilus involved with early interactions with pine trees.Systematic and searchable classification of cytochrome P450 proteins encoded by fungal and oomycete genomes.Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes).A binuclear zinc transcription factor binds the host isoflavonoid-responsive element in a fungal cytochrome p450 gene responsible for detoxification.Pharmacokinetic interactions of drugs with St John's wort.The evolutionary history of cytochrome P450 genes in four filamentous Ascomycetes.Co-up-regulation of three P450 genes in response to permethrin exposure in permethrin resistant house flies, Musca domestica.Genome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila.Cytochrome P450-null mice.Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues.Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum.Distribution of microsomal glutathione transferase 1 in mammalian tissues. A predominant alternate first exon in human tissues.Multiple Cytochrome P450 genes: their constitutive overexpression and permethrin induction in insecticide resistant mosquitoes, Culex quinquefasciatus.Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants.Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment.Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones.Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.Cytochromes P450 of insects: the tip of the iceberg.Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate.Human cytochromes P450: evolution and cDNA-directed expression.Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patientsOrphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology.Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways.
P2860
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P2860
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Evolution of the P450 gene sup ...... differences in drug oxidation.
@en
Evolution of the P450 gene sup ...... differences in drug oxidation.
@nl
type
label
Evolution of the P450 gene sup ...... differences in drug oxidation.
@en
Evolution of the P450 gene sup ...... differences in drug oxidation.
@nl
prefLabel
Evolution of the P450 gene sup ...... differences in drug oxidation.
@en
Evolution of the P450 gene sup ...... differences in drug oxidation.
@nl
P1433
P1476
Evolution of the P450 gene sup ...... differences in drug oxidation.
@en
P2093
Gonzalez FJ
P304
P356
10.1016/0168-9525(90)90174-5
P577
1990-06-01T00:00:00Z