The N-end rule pathway: emerging functions and molecular principles of substrate recognition.
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The N-end rule pathwayN-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathwayp600 Plays Essential Roles in Fetal DevelopmentTime-of-day- and light-dependent expression of ubiquitin protein ligase E3 component N-recognin 4 (UBR4) in the suprachiasmatic nucleus circadian clockThe ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpesvirus in endothelial cellsPyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsN-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporterThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseReal-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes.The UBR-box and its relationship to binuclear RING-like treble clef zinc fingersDownregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatinPlant arginyltransferases (ATEs).A neurostimulant para-chloroamphetamine inhibits the arginylation branch of the N-end rule pathway.UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.Hypomyelination with atrophy of the basal ganglia and cerebellum: further delineation of the phenotype and genotype-phenotype correlation.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy.Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 bindingEndoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocationCharacterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytesPharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.UUCD: a family-based database of ubiquitin and ubiquitin-like conjugationPerilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation.UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagyPosttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication.Measuring activity in the ubiquitin-proteasome system: from large scale discoveries to single cells analysisProtein Quality Control by Molecular Chaperones in Neurodegeneration.Frontiers of protein expression control with conditional degrons.Relationship between the proteasomal system and autophagy.Aberrant protein s-nitrosylation in neurodegenerative diseases.p600/UBR4 in the central nervous system.Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors.Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.Molecular definitions of autophagy and related processes.Physiological functions and clinical implications of the N-end rule pathway.Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.
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The N-end rule pathway: emerging functions and molecular principles of substrate recognition.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
The N-end rule pathway: emergi ...... ples of substrate recognition.
@en
The N-end rule pathway: emergi ...... ples of substrate recognition.
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type
label
The N-end rule pathway: emergi ...... ples of substrate recognition.
@en
The N-end rule pathway: emergi ...... ples of substrate recognition.
@nl
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The N-end rule pathway: emergi ...... ples of substrate recognition.
@en
The N-end rule pathway: emergi ...... ples of substrate recognition.
@nl
P2093
P356
P1476
The N-end rule pathway: emergi ...... ples of substrate recognition.
@en
P2093
Bo Yeon Kim
Shashikanth M Sriram
Yong Tae Kwon
P2888
P304
P356
10.1038/NRM3217
P577
2011-10-21T00:00:00Z
P6179
1023284906