Small molecule inhibitors of mammalian thioredoxin reductase.
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TrxR1 as a potent regulator of the Nrf2-Keap1 response systemThioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingIndolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leadsAcetaminophen reactive intermediates target hepatic thioredoxin reductasePolymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase.The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.Predicting the Cytotoxic Potency of Cigarette Smoke by Assessing the Thioredoxin Reductase Inhibitory Capacity of Cigarette Smoke Extract.Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.Thioredoxin reductase and its inhibitors.Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol.Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.Thioredoxin reductase inhibitors: a patent review.Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins.3-Nitro-2H-chromenes as a new class of inhibitors against thioredoxin reductase and proliferation of cancer cells.Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system.Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing.Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells.The Protective Effect of Selenium on Bovine Mammary Epithelial Cell Injury Caused by Depression of Thioredoxin Reductase.The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.A fast response and red emission probe for mammalian thioredoxin reductase.A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.Evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine as an irreversible inhibitor of mammalian thioredoxin reductase1.Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells.
P2860
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P2860
Small molecule inhibitors of mammalian thioredoxin reductase.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Small molecule inhibitors of mammalian thioredoxin reductase.
@en
Small molecule inhibitors of mammalian thioredoxin reductase.
@nl
type
label
Small molecule inhibitors of mammalian thioredoxin reductase.
@en
Small molecule inhibitors of mammalian thioredoxin reductase.
@nl
prefLabel
Small molecule inhibitors of mammalian thioredoxin reductase.
@en
Small molecule inhibitors of mammalian thioredoxin reductase.
@nl
P2093
P1476
Small molecule inhibitors of mammalian thioredoxin reductase
@en
P2093
Baolin Wang
Baoxin Zhang
Guanming Hu
Jianguo Fang
Liangwei Zhang
Wenqing Cai
Xuemei Cui
Yanlin Song
Yaping Liu
P304
P356
10.1016/J.FREERADBIOMED.2011.10.447
P50
P577
2011-10-21T00:00:00Z