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Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.A library of mammalian effector modules for synthetic morphologyp63 transcriptionally regulates the expression of matrix metallopeptidase 13.Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.Mitochondrial and postmitochondrial survival signaling in cancer.A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.The role of death-associated protein 3 in apoptosis, anoikis and human cancerTransmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosisA novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cellsFlexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry.Natural indoles, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosisCaspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease.The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer CellsSmall Molecule Active Site Directed Tools for Studying Human CaspasesTumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.SfDredd, a Novel Initiator Caspase Possessing Activity on Effector Caspase Substrates in Spodoptera frugiperdaCoenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation.Caspase-1 is a novel target of p63 in tumor suppression.MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen.Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in miceRescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases.Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.Live or let die: posttranscriptional gene regulation in cell stress and cell death.The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.Protease signaling in animal and plant-regulated cell death.Caspase-2: an orphan enzyme out of the shadows.Macrophage Apoptosis Triggered by IpaD from Shigella flexneri.Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition.Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system.Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen speciesCaspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis.IRE1, a double-edged sword in pre-miRNA slicing and cell death.IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective.Caspase-2 mediates triglyceride (TG)-induced macrophage cell death.NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance.Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells.A primer on caspase mechanisms.Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Caspase-2: the orphan caspase.
@en
Caspase-2: the orphan caspase.
@nl
type
label
Caspase-2: the orphan caspase.
@en
Caspase-2: the orphan caspase.
@nl
prefLabel
Caspase-2: the orphan caspase.
@en
Caspase-2: the orphan caspase.
@nl
P2860
P356
P1476
Caspase-2: the orphan caspase
@en
P2093
L Bouchier-Hayes
P2860
P2888
P356
10.1038/CDD.2011.157
P577
2011-11-11T00:00:00Z