PDE4: a novel target in the treatment of chronic obstructive pulmonary disease. - Wikidata - wikimedia - TriplyDB

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

http://www.wikidata.org/entity/Q37963175

about

Roflumilast: a review of its use in the treatment of COPD Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.Phosphodiesterase 4 inhibition in the treatment of psoriasis, psoriatic arthritis and other chronic inflammatory diseases.Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment Genome-guided discovery of diverse natural products from Burkholderia sp.Clinical application of expectorant therapy in chronic inflammatory airway diseases (Review).Phosphodiesterase-4 inhibitor therapy for lung diseases.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.Roflumilast partially reverses smoke-induced mucociliary dysfunction.Effect of a Dose-Escalation Regimen for Improving Adherence to Roflumilast in Patients with Chronic Obstructive Pulmonary Disease.Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.Synthesis of PDE IV inhibitors. First asymmetric synthesis of two of GlaxoSmithKline's highly potent Rolipram analogues.Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors.Synergy between 5-HT4 receptor stimulation and phosphodiesterase 4 inhibition in facilitating acetylcholine release in human large intestinal circular muscle.Theophylline Represses IL-8 Secretion from Airway Smooth Muscle Cells Independently of Phosphodiesterase Inhibition. Novel Role as a Protein Phosphatase 2A Activator.East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease.Advances in the synthesis of 7-(3-cyclopentyloxy-4-methoxyphenyl)-hexahydro-3H-pyrrolizin-3-one (Pyrromilast)–a promising agent for treatment of chronic obstructive pulmonary disease Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

P2860

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P2860

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

http://www.wikidata.org/entity/Q37963175

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

@zh-my

2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

@zh-hant

name

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@en

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@nl

type

label

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@en

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@nl

prefLabel

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@en

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@nl

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P1433

Clinical Pharmacology & Therapeutics

P1476

PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.

@en

P2093

G Golden

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J Ikari

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J M Michalski

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S I Rennard

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P2860

Global burden of COPD: systematic review and meta-analysis

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

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134-142

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scholarly article

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10.1038/CLPT.2011.266

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1

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91

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1046373347

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22130119

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chronic obstructive pulmonary disease