Lead-oriented synthesis: a new opportunity for synthetic chemistry.
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Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryEvaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like librariesParallel synthesis of 7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamides.2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles.A unified lead-oriented synthesis of over fifty molecular scaffolds.Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitorSynthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening.Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.A unified access to diverse heteroaromatic scaffolds using the radical chemistry of xanthates.Discovery of small molecule cancer drugs: successes, challenges and opportunities.System-based drug discovery within the human kinome.A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery.Synthesis and applications of rhodacyclopentanones derived from C-C bond activation.Recent advances in the chemistry of metallated azetidines.Unlocking the potential benefits of flow chemistry in the drug-discovery process.Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides.Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments.Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles.Palladium-Catalyzed Directed C(sp(3))-H Arylation of Saturated Heterocycles at C-3 Using a Concise Optimization ApproachAsymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods.Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization.Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl SulfideModular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition-Fragmentation Strategy.Embedding sustainable practices into pharmaceutical R&D: what are the challenges?Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol.Application of a robustness screen for the evaluation of synthetic organic methodology.Highly diastereoselective radical cyclisations of chiral sulfinimines.Reaction methodology: Speed dating for reactions.Coordination-Accelerated "Iron Extraction" Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles.Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery.C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery.
P2860
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P2860
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@en
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@nl
type
label
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@en
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@nl
prefLabel
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@en
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@nl
P2093
P2860
P356
P1476
Lead-oriented synthesis: a new opportunity for synthetic chemistry.
@en
P2093
Alan Nadin
Channa Hattotuwagama
Ian Churcher
P2860
P304
P356
10.1002/ANIE.201105840
P407
P577
2012-01-03T00:00:00Z