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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistryFlow "Fine" Synthesis: High Yielding and Selective Organic Synthesis by Flow MethodsSeamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example.An autonomous organic reaction search engine for chemical reactivityCharacterization and modeling of multiphase flow in structured microreactors: a post microreactor case study.Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating ReagentsRapid multistep kinetic model generation from transient flow data.Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions.Macrocycles in new drug discovery.Accessing new chemical entities through microfluidic systems.Tools for chemical synthesis in microsystems.Photochemical transformations accelerated in continuous-flow reactors: basic concepts and applications.The utilization of copper flow reactors in organic synthesis.Liquid phase oxidation chemistry in continuous-flow microreactors.Studies in organic and physical photochemistry - an interdisciplinary approach.Unlocking the potential benefits of flow chemistry in the drug-discovery process.Generation and Trapping of Ketenes in Flow.A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues.Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactorFlow carbonylation of sterically hindered ortho-substituted iodoarenes.A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.Cyclopropanation using flow-generated diazo compounds.Ruthenium carbenes supported on mesoporous silicas as highly active and selective hybrid catalysts for olefin metathesis reactions under continuous flow.Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry.Flow Asymmetric Propargylation: Development of Continuous Processes for the Preparation of a Chiral β-Amino Alcohol.The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?The assembly and use of continuous flow systems for chemical synthesis.A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems.The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.Solvent- and catalyst-free huisgen cycloaddition to rufinamide in flow with a greener, less expensive dipolarophile.A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.Pressure-accelerated azide-alkyne cycloaddition: micro capillary versus autoclave reactor performance.CHEMICAL SYNTHESIS. Going with the flow.Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds.7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir.Flow-Synthesis of Nucleosides Catalyzed by an Immobilized Purine Nucleoside Phosphorylase fromAeromonas hydrophila: Integrated Systems of Reaction Control and Product Purification
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Continuous flow synthesis. A pharma perspective.
@en
Continuous flow synthesis. A pharma perspective.
@nl
type
label
Continuous flow synthesis. A pharma perspective.
@en
Continuous flow synthesis. A pharma perspective.
@nl
prefLabel
Continuous flow synthesis. A pharma perspective.
@en
Continuous flow synthesis. A pharma perspective.
@nl
P356
P1476
Continuous flow synthesis. A pharma perspective.
@en
P2093
Flavien Susanne
Laia Malet-Sanz
P304
P356
10.1021/JM2006029
P407
P577
2012-02-27T00:00:00Z