Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.
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Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesHijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearanceMolecular basis of neurodegeneration and neurodevelopmental defects in Menkes diseaseMyelin Loss and Axonal Ion Channel Adaptations Associated with Gray Matter Neuronal HyperexcitabilityPhosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?Combined EXAFS and DFT structure calculations provide structural insights into the 1:1 multi-histidine complexes of Cu(II) , Cu(I) , and Zn(II) with the tandem octarepeats of the mammalian prion proteinCopper(I/II), α/β-Synuclein and Amyloid-β: Menage à Trois?Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats.A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicityInteraction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation.Study of the Serum Copper Levels in Patients with Major Depressive Disorder.New insights into metal interactions with the prion protein: EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion protein.Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress.Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases.Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes.The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons.The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.Unique structural properties associated with mouse prion Δ105-125 protein.Dual role of cellular prion protein in normal host and Alzheimer's disease.Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease.Elucidating the function of the prion protein.Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's diseaseAn ancient conserved role for prion protein in learning and memory.Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.Zinc, Carnosine, and Neurodegenerative Diseases.Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation.Functional ionotropic glutamate receptors on peripheral axons and myelin.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.Synaptic Effects of Dopamine Breakdown and Their Relation to Schizophrenia-Linked Working Memory Deficits.
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Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
@es
name
Copper-dependent regulation of ...... r neurodegenerative disorders.
@en
Copper-dependent regulation of ...... r neurodegenerative disorders.
@nl
type
label
Copper-dependent regulation of ...... r neurodegenerative disorders.
@en
Copper-dependent regulation of ...... r neurodegenerative disorders.
@nl
prefLabel
Copper-dependent regulation of ...... r neurodegenerative disorders.
@en
Copper-dependent regulation of ...... r neurodegenerative disorders.
@nl
P2860
P1476
Copper-dependent regulation of ...... or neurodegenerative disorders
@en
P2093
Haitao You
Peter K Stys
P2860
P304
P356
10.1113/JPHYSIOL.2011.225276
P407
P577
2012-02-06T00:00:00Z