Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseDiscovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ ReductionInhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell ModelA tale of two drug targets: the evolutionary history of BACE1 and BACE2Targeting the β secretase BACE1 for Alzheimer's disease therapy.Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease.Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's diseaseBACE2 as a new diabetes target: a patent review (2010 - 2012).Biological activities of guanidine compounds, 2008 - 2012 update.1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as BACE1 inhibitors: a patent evaluation of WO2013041499.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease.Design, synthesis and evaluation of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives as BACE-1 inhibitors.2,2,2-Trifluoroethyl-thiadiazines: a patent evaluation of WO2016023927.5-Amino-oxazepine and 5-Amino-thiazepine Compounds as β-Secretase Antagonists and Methods of Use: Patent Highlight.Compounds and Their Use as BACE Inhibitors: Patent Highlight.Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors.Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.γ-Secretase Modulators: Can We Combine Potency with Safety?Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Effect of sampling on BACE-1 ligands binding free energy predictions via MM-PBSA calculations.A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer's Disease.
P2860
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P2860
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
description
article científic
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article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
@en
type
label
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
@en
prefLabel
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
@en
P2860
P1476
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
@en
P2093
Gary Probst
Ying-zi Xu
P2860
P304
P356
10.1517/13543776.2012.681302
P407
P577
2012-04-19T00:00:00Z