Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
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The lethal toxin from Australian funnel-web spiders is encoded by an intronless geneDiscovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.Centipede venoms and their components: resources for potential therapeutic applicationsω-Tbo-IT1-New Inhibitor of Insect Calcium Channels Isolated from Spider Venom.The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channelsAnalysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1aThe insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loopA proteomics and transcriptomics investigation of the venom from the barychelid spider Trittame loki (brush-foot trapdoor)Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendamiConstraining cyclic peptides to mimic protein structure motifs.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouriToxin diversity revealed by a transcriptomic study of Ornithoctonus huwena.Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Venomous and poisonous Australian animals of veterinary importance: a rich source of novel therapeutics.Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesBacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Pathogen-inspired drug delivery to the central nervous system.An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.Recombinant expression and in vitro characterisation of active Huwentoxin-IV.The venom of the spider Selenocosmia jiafu contains various neurotoxins acting on voltage-gated ion channels in rat dorsal root ganglion neurons.Screening for voltage-gated sodium channel interacting peptides.Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.Pharmacological characterization of venoms from three theraphosid spiders: Poecilotheria regalis, Ceratogyrus darlingi and Brachypelma epicureanum.Molecular biology of insect sodium channels and pyrethroid resistance.Heterologous expression and purification of neurotoxic Hainantoxin-III in E. coli.Centipede venoms as a source of drug leads.Venom peptides as a rich source of cav2.2 channel blockers.Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs.Conduits of life's spark: a perspective on ion channel research since the birth of neuron.Evolution stings: the origin and diversification of scorpion toxin peptide scaffolds.Shellfish toxins targeting voltage-gated sodium channels.Transcriptome Analysis to Understand the Toxicity of Latrodectus tredecimguttatus Eggs.Advances in targeting voltage-gated sodium channels with small molecules.The insecticidal potential of venom peptides.
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P2860
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Spider-venom peptides that tar ...... d potential therapeutic leads.
@en
type
label
Spider-venom peptides that tar ...... d potential therapeutic leads.
@en
prefLabel
Spider-venom peptides that tar ...... d potential therapeutic leads.
@en
P2093
P50
P1433
P1476
Spider-venom peptides that tar ...... nd potential therapeutic leads
@en
P2093
Darshani B Rupasinghe
Julie K Klint
Sing Yan Er
P304
P356
10.1016/J.TOXICON.2012.04.337
P577
2012-04-20T00:00:00Z