Development of cascade reactions for the concise construction of diverse heterocyclic architectures.
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Palladium and organocatalysis: an excellent recipe for asymmetric synthesisThe ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis.Electrophile induced branching cascade: a powerful approach to access various molecular scaffolds and their exploration as novel anti-mycobacterial agents.A quadruple cascade protocol for the one-pot synthesis of fully-substituted hexahydroisoindolinones from simple substrates.Iron(II) bromide-catalyzed intramolecular C-H bond amination [1,2]-shift tandem reactions of aryl azides.Catalytic asymmetric tandem Friedel-Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromansHighly enantioselective dearomatizing formal [3+3] cycloaddition reactions of N-acyliminopyridinium ylides with electrophilic enol carbene intermediates.Pyrrolo[2,1-a]isoquinoline and pyrrole alkaloids from Sinomenium acutum.Radical cascade cyclization of 1,n-enynes and diynes for the synthesis of carbocycles and heterocycles.Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis.Streocontrolled construction of six vicinal stereogenic centers on spiropyrazolones via organocascade Michael/Michael/1,2-addition reactions.Organocatalytic Asymmetric Synthesis of Dihydroisoquinolinones via a One-Pot Aza-Henry-Hemiaminalization-Oxidation SequenceOrganocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes.Asymmetric synthesis of highly functionalized tetrahydropyrans via a one-pot organocatalytic Michael/Henry/ketalization sequence.Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction.Enantioselective Michael addition/iminium ion cyclization cascades of tryptamine-derived ureas.An Asymmetric Organocatalytic Quadruple Cascade to Tetraaryl-Substituted 2-Azabicyclo[3.3.0]octadienones.Asymmetric synthesis of fully substituted cyclopentane-oxindoles through an organocatalytic triple Michael domino reaction.Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes.An Asymmetric Organocatalytic Quadruple Domino Reaction Employing a Vinylogous Friedel-Crafts/Michael/Michael/Aldol Condensation Sequence.Asymmetric synthesis of tetrahydropyridines via an organocatalytic one-pot multicomponent Michael/aza-Henry/cyclization triple domino reaction.A branched domino reaction: asymmetric organocatalytic two-component four-step synthesis of polyfunctionalized cyclohexene derivatives.Highly efficient enantioselective construction of bispirooxindoles containing three stereocenters through an organocatalytic cascade Michael-cyclization reaction.Copper-catalyzed enantioselective Henry reaction of enals and subsequent iodocyclization: stereoselective construction of chiral azatricyclic frameworks.N-Heterocyclic carbene-catalyzed cascade reaction of 2-aroylvinylcinnamaldehydes with 2-aroylvinylchalcones: rapid assembly of six contiguous stereogenic centers with high diastereoselectivity.α,α-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones.Cascade nitrosation and addition-elimination of nitroacetanilides for the highly efficient synthesis of 1,4,2,5-dioxadiazine derivatives.Metal-containing carbonyl ylides: versatile reactants in catalytic enantioselective cascade reactions.Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction.Highly regio-, diastereo- and enantioselective deracemization of axially chiral 3-alkylideneoxindoles.Catalytic Asymmetric [3+1]-Cycloaddition Reaction of Ylides with Electrophilic Metallo-enolcarbene Intermediates.A Highly Enantioselective Copper/Phosphoramidite-Thioether-Catalyzed Diastereodivergent 1,3-Dipolar Cycloaddition of Azomethine Ylides and Nitroalkenes.One-pot asymmetric synthesis of a spiro[dihydrofurocoumarin/pyrazolone] scaffold by a Michael addition/I2-mediated cyclization sequence.Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity.Synthesis of stilbene derivatives via visible-light-induced cross-coupling of aryl diazonium salts with nitroalkenes using -NO2 as a leaving group.Regioselective multicomponent sequential synthesis of hydantoins.Organocatalyzed oxidative N-annulation for diverse and polyfunctionalized pyridines.Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence.A Copper-Catalyzed Decarboxylative Amination/Hydroamination Sequence: Switchable Synthesis of Functionalized Indoles.Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters.
P2860
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P2860
Development of cascade reactions for the concise construction of diverse heterocyclic architectures.
description
article científic
@ca
article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Development of cascade reactio ...... se heterocyclic architectures.
@en
type
label
Development of cascade reactio ...... se heterocyclic architectures.
@en
prefLabel
Development of cascade reactio ...... se heterocyclic architectures.
@en
P2093
P356
P1476
Development of cascade reactio ...... se heterocyclic architectures.
@en
P2093
Jia-Rong Chen
Liang-Qiu Lu
Wen-Jing Xiao
P304
P356
10.1021/AR200338S
P407
P577
2012-05-11T00:00:00Z