about
Idiosyncratic adverse drug reactions: current conceptsAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsThe Essential Medicinal Chemistry of CurcuminMapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.The essential roles of chemistry in high-throughput screening triagePAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes.Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.New Frontiers in DruggabilityProlonged and tunable residence time using reversible covalent kinase inhibitors.Designing Irreversible Inhibitors--Worth the Effort?Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr ResidueStructure, mechanism, and dynamics of UDP-galactopyranose mutase.Recent advances in irreversible kinase inhibitors.Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship StudyGuidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors.Targeted Covalent Inhibitors for Drug Design.Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.Road Map for the Structure-Based Design of Selective Covalent HCV NS3/4A Protease Inhibitors.Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.What Do Reactive Fragments Actually Do in Cells?Preparation of Reactive Oligo(p-Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments.The Taxonomy of Covalent InhibitorsProtein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling
P2860
Q26824391-3166B460-3A70-4E0F-8E9A-766EFCE73251Q27675997-13FA134F-895A-4672-A715-D33F173C1364Q29248430-F7C19A02-46D8-4878-966D-AD845491730BQ30841584-D94C1388-1859-4C49-A44A-5E44A5249234Q30842363-0A3144BB-A17B-4D81-B234-A97272FB92F3Q34435458-77E34866-661D-4687-B484-501B7E036C8FQ34460371-95C3B32E-A71A-40C5-A975-909F9280967CQ34489496-0817DB7A-772C-4CF9-8EE1-10E9B5EEF4F1Q34701319-E07B6E1F-3E3E-4412-B1AA-AAF0F34C01C7Q35008279-5EE8A67F-E0DE-415B-90F5-90A0D6070376Q35730955-16E0E848-1BC5-4474-B510-4E95F5B2B9AFQ35756228-8E5FDABA-201C-4B1E-9E07-832D15848CDDQ35848315-7A06A4FE-882F-462D-935B-85187E80FBD3Q36720905-CD1AC14E-BAAA-4A62-B036-6C725D3AFE22Q36949890-210F057D-CFB1-46FA-B6FB-5344471C1404Q37008862-99A46443-0BB1-47A7-84AD-4F1A9AE8020CQ37624622-D135EFF8-D841-488F-B6D3-1F03B15A8116Q38257746-2F4836C7-7DDA-41D5-A5C5-5B9D5AC4808AQ38778339-F63DC6E7-F993-463B-BF82-AFAAA691FDD9Q38878129-93C1D7BB-3612-488C-942A-E027D08FCF5BQ38931379-1AA8DCC2-5C52-427B-980C-0AA52AA3B9C5Q39869933-F96CEA69-E558-489A-9339-FE377563A1C3Q40080477-3A70FFBF-2619-4A25-A5F6-5B4141D43F53Q46156923-C585C8B9-7C6A-40B1-8698-522D6A609831Q48169096-F1E0C795-9D03-4C1B-8183-FEAB385216D3Q54573506-E4BA838E-42F8-40B9-BBB8-F09B48E08916Q56675654-4F61F657-1015-46E8-AA22-CE2D76452D2AQ56961708-76959331-2B9D-423A-9996-A428F7337BF0
P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Drug discovery for a new generation of covalent drugs.
@en
type
label
Drug discovery for a new generation of covalent drugs.
@en
prefLabel
Drug discovery for a new generation of covalent drugs.
@en
P2860
P1476
Drug discovery for a new generation of covalent drugs.
@en
P2093
Amit S Kalgutkar
Deepak K Dalvie
P2860
P304
P356
10.1517/17460441.2012.688744
P407
P577
2012-05-19T00:00:00Z