about
Grand challenges in cellular biochemistry: the "next-gen" biochemistryExpanding the chemical toolbox for the synthesis of large and uniquely modified proteins.Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.Nonenzymatic polymerization of ubiquitin: single-step synthesis and isolation of discrete ubiquitin oligomersThe challenge of producing ubiquitinated proteins for structural studiesGeneration of nonhydrolyzable ubiquitin-histone mimicsInsight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutationPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis.Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities.Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.Enzyme-catalyzed protein crosslinking.Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.Chemical strategies to understand the language of ubiquitin signaling.Using chemistry to investigate the molecular consequences of protein ubiquitylation.Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins.The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.Selective chemical labeling of proteins.Chemical and semisynthetic approaches to study and target deubiquitinases.Chemical ubiquitination for decrypting a cellular code.A native chemical ligation handle that enables the synthesis of advanced activity-based probes: diubiquitin as a case study.SUMOylated RanGAP1 prepared by click chemistry.Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology.Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches.A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis.Chemical Synthesis of Ubiquitin Chains.Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches.Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies.Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein.Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.One-pot chemical synthesis of small ubiquitin-like modifier protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates.Nonenzymatic rubylation and ubiquitination of proteins for structural and functional studies.Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.Intrinsic site-selectivity of ubiquitin dimer formation.A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.Genetic encoding of caged cysteine and caged homocysteine in bacterial and mammalian cells.E1-catalyzed ubiquitin C-terminal amidation for the facile synthesis of deubiquitinase substrates.N-methylation of isopeptide bond as a strategy to resist deubiquitinases.New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin.
P2860
Q28385256-348EE1FE-AD22-452C-9C98-EC62650B2FEEQ30387202-B77CAEAD-0EE2-4156-8BBB-48841151166FQ33785374-564C6381-4F1B-48D9-8600-727A135B08A7Q33852992-D5630FC3-ACA6-42DC-B28F-FF9399920A4CQ33883901-A8E30E49-EF26-47FB-AD35-1FF700EF800AQ34714983-F56CBC5E-963A-4271-9111-BAA3356615AAQ34997448-335E2102-B958-4108-A7B5-BA59F64AFC95Q35149828-99C24DCE-8519-4530-A484-F910FFA6BE77Q35687416-4D9797C9-5049-4108-B8FD-F9229352F4FDQ35823044-AD3B4053-C01D-44C5-A155-48CD1C94D050Q36537090-479D8875-2E92-421B-BB8C-2AC02CE6273EQ37276472-EB172837-6F47-483A-82E5-A946A050170EQ37313663-44AF3296-092C-4E2A-8BDA-EC0557476375Q37632117-AFE9E25B-8357-43E1-826D-B390F29DD2EAQ38098127-7BB5745B-9357-473E-9624-E340213EDB9CQ38224374-AC14A115-F45B-4701-95D8-D3E176FC1239Q38610434-7C820568-9F6C-4C5F-ADE9-A3745C64E41FQ38615247-D3FBADE7-37AD-47F4-8259-60445D325C42Q38759843-850ACEAD-80D7-4022-A01E-F6D930D1C40BQ38799376-06A561D4-8E4C-4F8F-82BD-6F181D73F9C8Q38840548-20991C11-AF2B-4712-8D2D-F2BC8FA4335AQ39016031-5ED94A07-BFA8-465B-9460-51E0DB07BD59Q39199904-D983D6F5-F8D0-4611-BB61-18AB798EF7E3Q39325962-D8FD0259-2AE9-41D9-AA8C-BB60E830DC86Q39336897-805A5D78-5B35-41E4-B3E0-7D2E67D3592AQ40092320-8EBE088B-C437-47C7-AB25-4B994DC0D9A5Q40250155-308EFE17-48B9-482C-A4ED-7E70BC42B03BQ40466750-ADCB6A07-9626-49E4-9B1B-8864D21C3429Q41109237-2362A27E-FA7A-4FA7-8C2A-878CFE4749C0Q41269525-05C5B124-A58F-4F0E-A86E-B337574402DDQ41420722-D77ABE9E-6CCD-40BA-9707-B917AAD0ECDCQ41579532-F19359E4-951E-44FB-BF50-04F69BF76EA0Q41844721-4CBC4D3F-8C48-44A6-917F-9FE2785575A2Q41896296-6AC1B4B6-97FC-4D77-856D-A6E240F2A8EFQ42063642-CC4DE953-21EC-44EE-8895-C52490821465Q42699301-59C63912-F938-4223-BDC7-30AB92E14A6CQ44874415-FF341341-E68D-4FAD-97C5-7CCCC7AE5FE8Q45183246-45999FFB-C714-4008-BB22-D1671706F4EDQ45710972-812EA3E0-BC19-403D-A96A-E500EB96A9DDQ45905318-05748A74-E57B-49A5-88BC-030A81E97CED
P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Chemistry and biology of the ubiquitin signal.
@en
type
label
Chemistry and biology of the ubiquitin signal.
@en
prefLabel
Chemistry and biology of the ubiquitin signal.
@en
P2860
P356
P1476
Chemistry and biology of the ubiquitin signal.
@en
P2093
Ashraf Brik
Liat Spasser
P2860
P304
P356
10.1002/ANIE.201200020
P407
P577
2012-06-13T00:00:00Z