Regulation of the transforming growth factor β pathway by reversible ubiquitylation. - Wikidata - wikimedia - TriplyDB

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

http://www.wikidata.org/entity/Q38020840

about

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6 Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.Activin A regulates activation of mouse neutrophils by Smad3 signalling Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer USP11 augments TGFβ signalling by deubiquitylating ALK5.OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.Deubiquitylases from genes to organism.Crosstalk between kinases and Nedd4 family ubiquitin ligases.The E3 ligase Itch in immune regulation and beyond.Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.Targeting endogenous proteins for degradation through the affinity-directed protein missile system.

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P2860

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

http://www.wikidata.org/entity/Q38020840

description

article científic

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article scientifique

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articol științific

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articolo scientifico

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artigo científico

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artigo científico

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artigo científico

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artikel ilmiah

@id

artikull shkencor

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artículo científico

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name

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

@en

type

label

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

@en

prefLabel

Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

@en

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Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

@en

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Gopal P Sapkota

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Lina Herhaus

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P275

Creative Commons Attribution 3.0 Unported

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

TGF-beta signal transduction

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

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120082

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scholarly article

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10.1098/RSOB.120082

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5

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2

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Mazin A Al-Salihi

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2012-05-01T00:00:00Z

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227858495

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22724073

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P921

regulation of gene expression

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3376735

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