Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.
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Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependenceAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksmGluR2 positive allosteric modulators: a patent review (2009 - present).Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Nociception modulation by supraspinal group III metabotropic glutamate receptors.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs.Structural characterization of two tetra-chlorido-zincate salts of 4-carb-oxy-1H-imidazol-3-ium: a salt hydrate and a co-crystal salt hydrate.Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats.Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics.Group II Metabotropic Glutamate Receptors: Role in Pain Mechanisms and Pain Modulation
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P2860
Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Recent progress in the synthes ...... eceptor allosteric modulators.
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type
label
Recent progress in the synthes ...... eceptor allosteric modulators.
@en
prefLabel
Recent progress in the synthes ...... eceptor allosteric modulators.
@en
P2093
P2860
P356
P1476
Recent progress in the synthes ...... receptor allosteric modulators
@en
P2093
Athina Markou
Douglas J Sheffler
Nicholas D P Cosford
Russell Dahl
P2860
P304
P356
10.1021/CN200008D
P577
2011-04-12T00:00:00Z