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A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's DiseaseRational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.A novel approach to rapidly prevent age-related cognitive declineThe Necessity of Having a Tetradentate Ligand to Extract Copper(II) Ions from Amyloids.Study of conformational changes and protein aggregation of bovine serum albumin in presence of Sb(III) and Sb(V).Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Chelation technology: a promising green approach for resource management and waste minimization.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity.3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.The role of ligand covalency in the selective activation of metalloenediynes for Bergman cyclization.Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.Link between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water-Soluble UV-Visible Ratiometric Dye with a Moderate Cu(II) Affinity.Anti-inflammatory activity of electron-deficient organometallics.Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer's disease.Exploring the boundaries of direct detection and characterization of labile isomers - a case study of copper(ii)-dipeptide systems.Characterization of new specific copper chelators as potential drugs for the treatment of Alzheimer's disease.A metallo pro-drug to target Cu(II) in the context of Alzheimer's disease.Thiol oxidase ability of copper ion is specifically retained upon chelation by aldose reductase.N4-Tetradentate chelators efficiently regulate copper homeostasis and prevent ROS production induced by copper-amyloid-β1-16, even in the presence of an excess of zinc.Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments.The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof.Partial conversion of thioamide into nitrile in a copper(II) complex of 2,6-diacetylpyridine bis(thiosemicarbazone), a drug prototype for Alzheimer's disease.Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway.Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Werner coordination chemistry and neurodegeneration.
@en
type
label
Werner coordination chemistry and neurodegeneration.
@en
prefLabel
Werner coordination chemistry and neurodegeneration.
@en
P2860
P356
P1476
Werner coordination chemistry and neurodegeneration.
@en
P2860
P304
P356
10.1039/C2CS35236B
P577
2012-09-05T00:00:00Z