The generation, detection, and effects of reactive drug metabolites.
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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaPost-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity.Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network.Practical approaches to resolving reactive metabolite liabilities in early discovery.Transglutaminase inhibitors: a patent review.The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury.Preparative microfluidic electrosynthesis of drug metabolites.Evaluation of the metabolism, bioactivation and pharmacokinetics of triaminopyrimidine analogs toward selection of a potential candidate for antimalarial therapy.Deep Learning to Predict the Formation of Quinone Species in Drug Metabolism.Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice.Quantitative monitoring of tamoxifen in human plasma extended to 40 metabolites using liquid-chromatography high-resolution mass spectrometry: new investigation capabilities for clinical pharmacologyRole of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors
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The generation, detection, and effects of reactive drug metabolites.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
The generation, detection, and effects of reactive drug metabolites.
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type
label
The generation, detection, and effects of reactive drug metabolites.
@en
prefLabel
The generation, detection, and effects of reactive drug metabolites.
@en
P2093
P2860
P356
P1476
The generation, detection, and effects of reactive drug metabolites.
@en
P2093
Abhishek Srivastava
Alvin J L Chia
Andrew V Stachulski
B Kevin Park
Christopher E P Goldring
Daniel J Antoine
Dean J Naisbitt
Deepak K Dalvie
Dominic P Williams
Hayley Callan
P2860
P304
P356
10.1002/MED.21273
P577
2012-10-22T00:00:00Z