Tuning the molecular giant titin through phosphorylation: role in health and disease.
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Heart failure with preserved ejection fraction: emerging drug strategiesA Review of the Giant Protein Titin in Clinical Molecular Diagnostics of CardiomyopathiesGenetics and disease of ventricular muscle.Tracks through the genome to physiological eventsProtein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertensionIdentification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy.Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study.Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle ForceCardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.A Perspective on the Role of Myosins as MechanosensorsCombination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction.Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.Mechanisms modulating skeletal muscle phenotype.Targeted proteomics of myofilament phosphorylation and other protein posttranslational modifications.Cell- and molecular-level mechanisms contributing to diastolic dysfunction in HFpEFRBM20, a potential target for treatment of cardiomyopathy via titin isoform switching.Mechanics of Vascular Smooth Muscle.Quantitative MRI biomarkers to characterize regional left ventricular perfusion and function in nonhuman primates during dobutamine-induced stress: A reproducibility and reliability study.Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle.Myosin filament activation in the heart is tuned to the mechanical task.The giant protein titin regulates the length of the striated muscle thick filament.Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy.Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing.Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task.Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
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Tuning the molecular giant titin through phosphorylation: role in health and disease.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Tuning the molecular giant titin through phosphorylation: role in health and disease.
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type
label
Tuning the molecular giant titin through phosphorylation: role in health and disease.
@en
prefLabel
Tuning the molecular giant titin through phosphorylation: role in health and disease.
@en
P2860
P1476
Tuning the molecular giant titin through phosphorylation: role in health and disease.
@en
P2093
Carlos Hidalgo
Henk Granzier
P2860
P304
P356
10.1016/J.TCM.2012.10.005
P577
2013-01-05T00:00:00Z